Targeted metabolomics

LD Roberts, AL Souza, RE Gerszten… - Current protocols in …, 2012 - Wiley Online Library
The metabolome is the terminal downstream product of the genome and consists of the total
complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or …

Biomarker discovery and translation in metabolomics

GA Nagana Gowda, D Raftery - Current Metabolomics, 2013 - ingentaconnect.com
The multifaceted field of metabolomics has witnessed exponential growth in both methods
development and applications. Owing to the urgent need, a significant fraction of research …

Targeted metabolomics and mass spectrometry

E Dudley, M Yousef, Y Wang, WJ Griffiths - Advances in protein chemistry …, 2010 - Elsevier
While a great emphasis has been placed on global metabolomic analysis in recent years,
the application of metabolomic style analyses to specific subsets of compounds (targeted …

Untargeted metabolomics

N Vinayavekhin, A Saghatelian - Current protocols in molecular …, 2010 - Wiley Online Library
Along with genes and proteins, metabolites play important roles in sustaining life. Their
functions include “primary” functions in metabolism and energy storage, as well as …

[HTML][HTML] Understanding metabolomics in biomedical research

SJ Kim, SH Kim, JH Kim, S Hwang… - Endocrinology and …, 2016 - synapse.koreamed.org
The term" omics" refers to any type of specific study that provides collective information on a
biological system. Representative omics includes genomics, proteomics, and metabolomics …

Exploring disease through metabolomics

N Vinayavekhin, EA Homan… - ACS chemical biology, 2010 - ACS Publications
Metabolomics approaches provide an analysis of changing metabolite levels in biological
samples. In the past decade, technical advances have spurred the application of …

Untargeted metabolomics strategies—challenges and emerging directions

AC Schrimpe-Rutledge, SG Codreanu… - Journal of the …, 2016 - ACS Publications
Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …

[HTML][HTML] Human metabolomics: strategies to understand biology

R Ramautar, R Berger, J van der Greef… - Current opinion in …, 2013 - Elsevier
Highlights•Metabolomics provides a functional read-out of the physiological status of an
organism.•A precise (dynamic) description of the clinical phenotype is missing for complex …

MetaboLights: an open‐access database repository for metabolomics data

NS Kale, K Haug, P Conesa… - Current protocols in …, 2016 - Wiley Online Library
MetaboLights is the first general purpose, open‐access database repository for cross‐
platform and cross‐species metabolomics research at the European Bioinformatics Institute …

Challenges in mass spectrometry based targeted metabolomics

T Koal, HP Deigner - Current molecular medicine, 2010 - ingentaconnect.com
The gap of the post-genomic era is increasingly being filled by the metabolomics approach,
comprising a technology for analyzing small molecule endogenous metabolites (≤ 1500 …