Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells

KM Kodigepalli, P Anur, P Spellman, PJ Sims… - Molecular cancer, 2013 - Springer
Background Treatment of advanced stage ovarian cancer continues to be challenging due
to acquired drug resistance and lack of early stage biomarkers. Genes identified to be …

RNA interference‑mediated downregulation of phospholipid scramblase 1 expression in primary liver cancer in vitro

L Gui, YW Zhu, Q Xu, JJ Huang, P Hua… - Oncology …, 2020 - spandidos-publications.com
Abstract Phospholipid scramblase 1 (PLSCR1) serves a function in the pathogenesis and
progression of various types of cancer. However, the role of PLSCR1 in human primary liver …

Snail interacts with hPLSCR1 promoter and down regulates its expression in IMR-32

VG Francis, P Padmanabhan, SN Gummadi - Biochemical and Biophysical …, 2014 - Elsevier
Abstract Human phospholipid scramblase 1 (hPLSCR1) is a proapoptotic protein whose
expression is deregulated in a variety of cancers cells. However till date the transcription …

Suppression of Ovarian Carcinoma Cell Growth in Vivo by the Interferon-inducible Plasma Membrane Protein, Phospholipid Scramblase 1

RH Silverman, A Halloum, A Zhou, B Dong… - Cancer research, 2002 - AACR
Abstract Phospholipid scramblase 1 (PLSCR1) is an IFN-inducible, endofacial plasma
membrane protein that has been proposed to mediate accelerated transbilayer movement of …

Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells

Y Huang, Q Zhao, CX Zhou, ZM Gu, D Li, HZ Xu… - Oncogene, 2006 - nature.com
Abstract Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated protein which is
localized in either the cell membrane or nucleus depending on its palmitoylated state. The …

Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo

CW Fan, CY Chen, KT Chen, CR Shen, YB Kuo… - Journal of translational …, 2012 - Springer
Background Membrane-bound phospholipid scramblase 1 (PLSCR1) is involved in both
lipid trafficking and cell signaling. Previously, we showed that PLSCR1 is overexpressed in …

[HTML][HTML] Overexpression of SnoN/SkiL, amplified at the 3q26. 2 locus, in ovarian cancers: a role in ovarian pathogenesis

M Nanjundan, KW Cheng, F Zhang, J Lahad, WL Kuo… - Molecular …, 2008 - Elsevier
High-resolution array comparative genomic hybridization of 235 serous epithelial ovarian
cancers demonstrated a regional increase at 3q26. 2 encompassing SnoN/SkiL, a …

Phospholipid scramblase 1.

Y Huang, Q Zhao, GQ Chen - Sheng li xue bao:[Acta Physiologica …, 2006 - europepmc.org
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II
endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import …

Interferon-α-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cδ and JNK

KW Zhao, D Li, Q Zhao, Y Huang, RH Silverman… - Journal of Biological …, 2005 - ASBMB
Phospholipid scramblase 1 (PLSCR1), a calcium-binding protein that either inserts into the
plasma membrane or binds to genomic DNA in the nucleus, has been shown to contribute to …

Silencing phospholipid scramblase 1 expression by RNA interference in colorectal cancer and metastatic liver cancer

W Cui, SY Li, JF Du, ZM Zhu, P An - Hepatobiliary & pancreatic diseases …, 2012 - Elsevier
Background Phospholipid scramblase 1 (PLSCR1) not only participates in the transbilayer
movement of phospholipids, but also plays a role in the pathogenesis and progression of …