The role of autophagy in the pathogenesis of diabetic nephropathy

K Yamahara, M Yasuda, S Kume… - Journal of diabetes …, 2013 - Wiley Online Library
Diabetic nephropathy is a leading cause of end‐stage renal disease worldwide. The
multipronged drug approach targeting blood pressure and serum levels of glucose, insulin …

Autophagy: emerging therapeutic target for diabetic nephropathy

S Kume, K Yamahara, M Yasuda, H Maegawa… - Seminars in …, 2014 - Elsevier
Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle
macromolecules and organelles. It plays a critical role in removing protein aggregates, as …

Autophagy as a therapeutic target in diabetic nephropathy

Y Tanaka, S Kume, M Kitada… - Journal of Diabetes …, 2012 - Wiley Online Library
Diabetic nephropathy is a serious complication of diabetes mellitus, and its prevalence has
been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic …

Autophagy: a novel therapeutic target for diabetic nephropathy

S Kume, D Koya - Diabetes & metabolism journal, 2015 - synapse.koreamed.org
Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is
increasing worldwide. The most effective treatment strategy for the condition is intensive …

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

D Yang, MJ Livingston, Z Liu, G Dong, M Zhang… - Cellular and Molecular …, 2018 - Springer
Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

[PDF][PDF] The activity and role of autophagy in the pathogenesis of diabetic nephropathy.

WJ Liu, WF Huang, L Ye, RH Chen… - European Review for …, 2018 - europeanreview.org
OBJECTIVE: Evidence suggested that deficiency of autophagy is involved in the
pathogenesis of diabetic nephropathy (DN). However, some recent studies have also shown …

[HTML][HTML] Autophagy in diabetic nephropathy

Y Ding, ME Choi - The Journal of endocrinology, 2015 - ncbi.nlm.nih.gov
Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

Autophagy and diabetic nephropathy

J Cui, X Bai, X Chen - Autophagy: Biology and Diseases: Clinical Science, 2020 - Springer
In recent years, diabetic kidney disease has been the main cause of end-stage renal
disease; more and more people have faced this serious public health problem worldwide …

Regulating autophagy as a therapeutic target for diabetic nephropathy

M Kitada, Y Ogura, I Monno, D Koya - Current diabetes reports, 2017 - Springer
Abstract Purpose of Review Autophagy promotes cellular health in response to various
cellular stresses and to changes in nutrient conditions. In this review, we focus on the role of …

The critical role of dysregulated autophagy in the progression of diabetic kidney disease

Z Zhang, Y Sun, J Xue, D Jin, X Li, D Zhao… - Frontiers in …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) is one of the major public health problems in society today. It
is a renal complication caused by diabetes mellitus with predominantly microangiopathy and …