CHEK2 is a key cell cycle control gene encoding a pluripotent kinase that can cause arrest
or apoptosis in response to unrepaired DNA damage. We report a large case-control study …

Mutations in the CHEK2 gene have been associated with increased risks of breast, prostate
and colon cancer. In contrast, a previous report suggests that individuals with the I157T …

In clinical practice, there are a number of cancer patients with clear family histories, but the
patients lack mutations in known familial cancer syndrome genes. Recent advances in …

CHEK2 is a tumor suppressor gene whose functions are central to the induction of cell cycle
arrest and apoptosis following DNA damage. Mutations in CHEK2 have been associated …

The CHEK2 1100delC protein-truncating mutation has a carrier frequency of∼ 0.7% in
Northern and Western European populations and confers an∼ 2-fold increased risk of …

Background: Germline mutations in the Chek2 kinase gene (CHEK2) have been associated
with a range of cancer types. Recently, a large deletion of exons 9 and 10 of CHEK2 was …

Purpose CHEK2 is a cell cycle checkpoint regulator, and the CHEK2* 1100delC germline
mutation leads to loss of function and increased breast cancer risk. It seems plausible that …

A single founder allele of the CHEK2 gene has been associated with predisposition to
breast and prostate cancer in North America and Europe. The CHEK2 protein participates in …

Abstract Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in
the DNA damage checkpoint response cascade. We first investigated two polymorphisms in …

Predisposing CHEK2 germline variants are associated with various adult‐type
malignancies, whereas their impact on cancer susceptibility in childhood cancer is unclear …