Somatostatin (SRIF), a tetradecapeptide discovered by Brazeau et al., has been shown to
have potent inhibitory effects on various secretory processes in tissues such as pituitary …

The effect of somatostatin (SRIF) analogs on the secretion of radioimmunoassayable SRIF
(SRIF-LI) was studied in the model system of fetal rat hypothalamus cells maintained in long …

Somatostatin-14 was discovered in 1973 in the hypothalamus as a peptide inhibiting growth
hormone release. Somatostatin interacts with five receptor subtypes (sst1− 5) which are …

The PCR and conventional library screening were used to clone the brain-specific
somatostatin receptor rSSTR-4 from a rat genomic library. The deduced amino acid …

The inhibitory neuropeptide somatostatin regulates several functions in the nervous system
including memory. Its concentrations decrease by age leading to functional alterations, but …

Somatostatin is a neuromodulator in the mammalian CNS. To date, genes for at least five
different somatotrophin release inhibiting factor receptors, termed sst1–sst5, have been …

Insulin-like growth factor I (IGF-I) has been shown to participate in feedback inhibition of
growth hormone (GH) secretion at the level of both the pituitary and hypothalamus …

Somatostatin (SST) is one of the major peptide transmitters in the mammalian central
nervous system and also seems to exert specific functions during brain development. In …

The neuropeptide somatostatin (SRIF) is widely expressed in the brain and in the periphery
in two main forms, SRIF-14 and SRIF-28. Similarly, the presence of SRIF receptors …

Somatostatin (SRIF) pathways in rat brain were investigated by measurement of
radioimmunoassayable SRIF in median eminence (ME), preoptic area (POA), amygdala and …