Recent advances in hyaluronic acid hydrogels for biomedical applications

CB Highley, GD Prestwich, JA Burdick - Current opinion in biotechnology, 2016 - Elsevier
Highlights•New modifications to hyaluronic acid (HA) enable both covalent crosslinking and
supramolecular assembly.•Composite HA hydrogels permit controlled drug delivery and …

Application of hyaluronic acid as carriers in drug delivery

G Huang, H Huang - Drug delivery, 2018 - Taylor & Francis
Hyaluronic acid has good biocompatibility, biodegradability, and nonimmunogenicity. In
addition, it has the ability to recognize specific receptors that are overexpressed on the …

Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin

MB Brown, SA Jones - Journal of the European Academy of …, 2005 - Wiley Online Library
Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N‐
acetyl‐d‐glucosamine and β‐glucoronic acid. It is present in the intercellular matrix of most …

Hyaluronic acid: redefining its role

G Abatangelo, V Vindigni, G Avruscio, L Pandis, P Brun - Cells, 2020 - mdpi.com
The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has
promoted new research impetus for biologists and, the clinical interest in several fields of …

Hyaluronic acid for advanced therapies: Promises and challenges

N Gallo, H Nasser, L Salvatore, ML Natali… - European Polymer …, 2019 - Elsevier
Hyaluronic acid (HA), also termed hyaluronan, is a key extracellular matrix
glycosaminoglycan that not only provides tissue hydration, but also shows intrinsic …

Hyaluronic acid-based prodrug nanomedicines for enhanced tumor targeting and therapy: A review

R Zhang, X Zhao, A Jia, C Wang, H Jiang - International Journal of …, 2023 - Elsevier
Hyaluronic acid (HA) represents a natural polysaccharide which has attracted significant
attention owing to its improved tumor targeting capacity, enzyme degradation capacity, and …

Hyaluronic acid hydrogels crosslinked in physiological conditions: Synthesis and biomedical applications

LA Pérez, R Hernández, JM Alonso, R Pérez-González… - Biomedicines, 2021 - mdpi.com
Hyaluronic acid (HA) hydrogels display a wide variety of biomedical applications ranging
from tissue engineering to drug vehiculization and controlled release. To date, most of the …

Hyaluronic acid and its derivatives in coating and delivery systems: applications in tissue engineering, regenerative medicine and immunomodulation

H Knopf‐Marques, M Pravda, L Wolfova… - Advanced …, 2016 - Wiley Online Library
As an Extracellular Matrix (ECM) component, Hyaluronic acid (HA) plays a multi‐faceted role
in cell migration, proliferation and differentiation at micro level and system level events such …

Hyaluronic acid-based theranostic nanomedicines for targeted cancer therapy

SY Lee, MS Kang, WY Jeong, DW Han, KS Kim - Cancers, 2020 - mdpi.com
Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages,
including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity …

Chemically-modified HA for therapy and regenerative medicine

GD Prestwich, J Kuo - Current pharmaceutical biotechnology, 2008 - ingentaconnect.com
Hyaluronan (HA) is a very useful polymer, but its properties sometimes need to be altered or
enhanced by chemical modification for biomedical applications. A wide variety of HA …