The p14 alternate reading frame (ARF) tumor suppressor plays a central role in cancer by
binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA …

The p53-mediated pathway cell cycle arrest and apoptosis is central to cancer and an
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …

Abstract The p53/p14ARF/mdm2 stress response pathway plays a central role in mediating
cellular responses to oncogene activation, genome instability, and therapy-induced DNA …

The ARF tumor suppressor is widely regarded as an upstream activator of p53-dependent
growth arrest and apoptosis. However, recent findings indicate that ARF can also regulate …

Ionizing radiation leads to rapid stabilization and activation of the p53 tumor suppressor.
Previous reports demonstrate that murine p19ARF cooperates with p53 in the cellular …

The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …

The Arf tumor suppressor inhibits cell cycle progression through both p53-dependent and
p53-independent mechanisms, including interference with rRNA processing. Using tandem …

The ARF tumor suppressor is a central component of the cellular defense against oncogene
activation in mammals. p14ARF activates p53 by binding and inhibiting HDM2, resulting …

p14ARF, the alternative product from the human INK4a/ARF locus, antagonizes Hdm2 and
mediates p53 activation in response to oncogenic stimuli. An immunohistochemical study of …

The MDM2 protein targets the p53 tumor suppressor for ubiquitin-dependent degradation
[1], and can function both as an E3 ubiquitin ligase [2] and as a regulator of the subcellular …