Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

The p53 tumour suppressor protein is down-regulated by the action of Mdm2, which targets
p53 for rapid degradation by the ubiquitin-proteasome pathway. The p14 ARF protein is also …

The nucleolus is the center of ribosome synthesis, with the nucleophosmin (NPM) and
p19ARF proteins antagonizing one another to either promote or inhibit growth. However …

The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation.
Ubiquitination of p53 is regulated by ARF, which binds to MDM2 and inhibits its E3 ligase …

The tumor suppressor ARF plays an essential role in the cellular response to oncogenic
stress mainly through activation of p53. Nucleophosmin (NPM), a multifunctional protein …

Although the importance of the ARF tumor suppressor in p53 regulation is well established,
numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2 …

The tumour suppressor ARF is specifically required for p53 activation under oncogenic
stress,,,,,. Recent studies showed that p53 activation mediated by ARF, but not that induced …

Pathways involving p53 and pRb tumor suppressor genes are frequently deregulated during
lung carcinogenesis. Through its location at the interface of these pathways, Mdm2 can …

Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …

The INK4a-ARF locus encodes two distinct tumor suppressors, p16INK4a and p19ARF.
Whereas p16INK4a restrains cell growth through preventing phosphorylation of the …