Divorcing ARF and p53: an unsettled case
CJ Sherr - Nature Reviews Cancer, 2006 - nature.com
Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
CA Midgley, JMP Desterro, MK Saville, S Howard… - Oncogene, 2000 - nature.com
The p53 tumour suppressor protein is down-regulated by the action of Mdm2, which targets
p53 for rapid degradation by the ubiquitin-proteasome pathway. The p14 ARF protein is also …
p53 for rapid degradation by the ubiquitin-proteasome pathway. The p14 ARF protein is also …
A Non-Tumor Suppressor Role for Basal p19ARF in Maintaining Nucleolar Structure and Function
AJ Apicelli, LB Maggi Jr, AC Hirbe… - … and cellular biology, 2008 - Taylor & Francis
The nucleolus is the center of ribosome synthesis, with the nucleophosmin (NPM) and
p19ARF proteins antagonizing one another to either promote or inhibit growth. However …
p19ARF proteins antagonizing one another to either promote or inhibit growth. However …
MDM2-ARF complex regulates p53 sumoylation
L Chen, J Chen - Oncogene, 2003 - nature.com
The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation.
Ubiquitination of p53 is regulated by ARF, which binds to MDM2 and inhibits its E3 ligase …
Ubiquitination of p53 is regulated by ARF, which binds to MDM2 and inhibits its E3 ligase …
Reactivating the ARF-p53 axis in AML cells by targeting ULF
The tumor suppressor ARF plays an essential role in the cellular response to oncogenic
stress mainly through activation of p53. Nucleophosmin (NPM), a multifunctional protein …
stress mainly through activation of p53. Nucleophosmin (NPM), a multifunctional protein …
[HTML][HTML] ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
D Chen, N Kon, M Li, W Zhang, J Qin, W Gu - Cell, 2005 - cell.com
Although the importance of the ARF tumor suppressor in p53 regulation is well established,
numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2 …
numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2 …
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
The tumour suppressor ARF is specifically required for p53 activation under oncogenic
stress,,,,,. Recent studies showed that p53 activation mediated by ARF, but not that induced …
stress,,,,,. Recent studies showed that p53 activation mediated by ARF, but not that induced …
Mdm2 overexpression and p14ARF inactivation are two mutually exclusive events in primary human lung tumors
B Eymin, S Gazzeri, C Brambilla, E Brambilla - Oncogene, 2002 - nature.com
Pathways involving p53 and pRb tumor suppressor genes are frequently deregulated during
lung carcinogenesis. Through its location at the interface of these pathways, Mdm2 can …
lung carcinogenesis. Through its location at the interface of these pathways, Mdm2 can …
Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis
Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …
P19ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
W Tao, AJ Levine - Proceedings of the National Academy of …, 1999 - National Acad Sciences
The INK4a-ARF locus encodes two distinct tumor suppressors, p16INK4a and p19ARF.
Whereas p16INK4a restrains cell growth through preventing phosphorylation of the …
Whereas p16INK4a restrains cell growth through preventing phosphorylation of the …