Identification of a cryptic nucleolar-localization signal in MDM2
MAE Lohrum, M Ashcroft, MHG Kubbutat… - Nature cell …, 2000 - nature.com
* NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick, Maryland 21702-1201,
USA† Present address: Institute of Molecular Medicine, Tumor Biology Center, Breisacher …
USA† Present address: Institute of Molecular Medicine, Tumor Biology Center, Breisacher …
ARF the Integrator: Linking NF-? B, p53 and Checkpoint Kinases
S Rocha, ND Perkins - Cell Cycle, 2005 - Taylor & Francis
The ARF tumour suppressor initiates the cellular response to aberrant oncogeneactivation
through binding to and inhibiting the activity of Hdm2/Mdm2, the inhibitor ofp53. However …
through binding to and inhibiting the activity of Hdm2/Mdm2, the inhibitor ofp53. However …
p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF
L Xia, A Paik, JJ Li - Cancer research, 2004 - AACR
Mammalian cells chronically exposed to ionizing radiation (IR) induce stress response with
a tolerance to the subsequent cytotoxicity of IR. Although p53 is well documented in IR …
a tolerance to the subsequent cytotoxicity of IR. Although p53 is well documented in IR …
The exogenous wild-type p14ARF gene induces growth arrest and promotes radiosensitivity in human lung cancer cell lines
N Gao, YD Hu, XY Cao, J Zhou, SL Cao - Journal of cancer research and …, 2001 - Springer
The cyclin-dependent kinase inhibitor p16INK4a encoded by the INK4A/CDKN2A/MTS1
gene is a frequent target of 9p21 inactivation in human lung cancers. The p14ARF transcript …
gene is a frequent target of 9p21 inactivation in human lung cancers. The p14ARF transcript …
RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis
AJ Saporita, HC Chang, CL Winkeler, AJ Apicelli… - Cancer research, 2011 - AACR
The p19ARF tumor suppressor limits ribosome biogenesis and responds to
hyperproliferative signals to activate the p53 checkpoint response. Although its activation of …
hyperproliferative signals to activate the p53 checkpoint response. Although its activation of …
[HTML][HTML] Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
The mammalian ARF-INK4a locus uniquely encodes two cell cycle inhibitors by using
separate promoters and alternative reading frames. p16 INK4a maintains the retinoblastoma …
separate promoters and alternative reading frames. p16 INK4a maintains the retinoblastoma …
[HTML][HTML] Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc
The tumor suppressor protein ARF (alternate reading frame) inhibits MDM2 to stabilize and
activate the functions of p53. Here we provide evidence for an additional activity of ARF that …
activate the functions of p53. Here we provide evidence for an additional activity of ARF that …
Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis
ARF encodes a potent tumor suppressor that antagonizes MDM2, a negative regulator of
p53. ARF also suppresses the proliferation of cells lacking p53, and loss of ARF in p53-null …
p53. ARF also suppresses the proliferation of cells lacking p53, and loss of ARF in p53-null …
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
MDM2 is a RING domain ubiquitin E3 ligase and a major regulator of the p53 tumor
suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 …
suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 …
[HTML][HTML] A major functional difference between the mouse and human ARF tumor suppressor proteins
Suppression of tumorigenesis is considerably more stringent in the human than in the much
shorter lived mouse species, and the reasons for this difference are poorly understood. We …
shorter lived mouse species, and the reasons for this difference are poorly understood. We …