Objectives We explored histological and transcriptomic profiles of paired synovial biopsies
from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at …

Genetic and immunological evidence clearly points to a role for T cells in the pathogenesis
of rheumatoid arthritis (RA). Selective targeting of such disease-associated T cell clones …

Rheumatoid arthritis (RA) is an autoimmune disease initiated by antigen-specific T cells and
B cells, which promote synovial inflammation through a complex set of interactions with …

Objectives Early diagnosis of rheumatoid arthritis (RA) is an unmet medical need in the field
of rheumatology. Previously, we performed high-density transcriptomic studies on synovial …

Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B
cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue …

Objectives This study investigates pathogenic and protective polyfunctional T-cell responses
in patient with rheumatoid arthritis (RA), individuals at risk (IAR) and healthy control (HC) …

Objectives Transcriptomic profiling of synovial tissue from patients with early, untreated
rheumatoid arthritis (RA) was used to explore the ability of unbiased, data-driven …

Objective CD4+ T cells are implicated in rheumatoid arthritis (RA) pathology from the strong
association between RA and certain HLA class II gene variants. This study was undertaken …

Objectives Systemic immunological processes are profoundly shaped by the micro-
environments where antigen recognition occurs. Identifying molecular signatures distinctive …

Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has
identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T …