Objectives Anticitrullinated protein antibody (ACPA)+ individuals with non-specific
musculoskeletal symptoms are at risk of inflammatory arthritis (IA). This study aims to …

Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory
processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical …

Objectives The therapeutic goal for patients with rheumatoid arthritis (RA) is clinical
remission. This is best achieved by early diagnosis and appropriate therapeutic intervention …

Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting systemic synovial
tissues, leading to the destruction of multiple joints. Its etiology is still unknown, but T-cell …

Rheumatoid arthritis (RA) is a chronic autoimmune, inflammatory disease, characterized by
synovitis in small-and medium-sized joints and, if not treated early and efficiently, joint …

Background: Circulating regulatory T cells (Tregs) are responsible for mediating immune
tolerance and maintaining immunological homeostasis. Decreases in Tregs may be …

The contribution of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA) remains a
matter of intense debate. Few people, however, would question the central role of T cells in …

Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of
rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition …

Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it
is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B …

Objective RA encompasses a complex, heterogeneous and dynamic group of diseases
arising from molecular and cellular perturbations of synovial tissues. The aim of this study …