Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble …

L Fang, Q Zhao, C Guo, D Guo, Z Li, J Xu, C Guo… - Frontiers in …, 2022 - frontiersin.org
Plant-derived polysaccharides have demonstrated promising anti-cancer effects via immune-
regulatory activity. The aim of the current study was to compare the chemical property and …

Polysaccharides from sporoderm‑removed spores of Ganoderma lucidum induce apoptosis in human gastric cancer cells via disruption of autophagic flux

J Zhong, L Fang, R Chen, J Xu, D Guo… - Oncology …, 2021 - spandidos-publications.com
The sporoderm‑broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP)
have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to …

Polysaccharides of Sporoderm‐Broken Spore of Ganoderma lucidum Modulate Adaptive Immune Function via Gut Microbiota Regulation

L Su, D Li, J Su, E Zhang, S Chen… - Evidence‐Based …, 2021 - Wiley Online Library
Ganoderma lucidum (Leyss. Fr.) Karst is one of the well‐known medicinal macrofungi all
over the world, and mounting researches have focused on the polysaccharides derived from …

Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum

PY Wang, XL Zhu, ZB Lin - Frontiers in pharmacology, 2012 - frontiersin.org
The antitumor and immunomodulatory activity of broken-spore of Ganoderma lucidum
polysaccharides (Gl-BSP) were investigated in vivo and in vitro. It was showed that Gl-BSP …

Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis

M Song, Z Li, H Gu, R Tang, R Zhang… - Journal of …, 2021 - Wiley Online Library
Background. Ganoderma lucidum has certain components with known pharmacological
effects, including strengthening immunity and anti‐inflammatory activity. G. lucidum seeds …

Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs via a CARD9-NF-κB-IDO …

Y Wang, X Fan, X Wu - Bioscience Reports, 2020 - portlandpress.com
A homogeneous polysaccharide (GLP), with an average molecular weight of 4.44× 104 Da,
was isolated and purified from the fruiting bodies of Ganoderma lucidum. In this work, we …

Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis

JH Bai, J Xu, J Zhao, R Zhang - Cell Transplantation, 2020 - journals.sagepub.com
Ganoderma lucidum is a popular traditional Chinese medicine used in China to improve
health. Previous researches have revealed that the polysaccharide from G. lucidum could …

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

C Guo, D Guo, L Fang, T Sang, J Wu, C Guo… - Carbohydrate …, 2021 - Elsevier
This study investigated the effects of water-soluble polysaccharide extracted from the
sporoderm-removed spores of Ganoderma lucidum (GLP) against AOM/DSS-induced …

Antitumor effects of different Ganoderma lucidum spore powder in cell-and zebrafish-based bioassays

Y Shi, H Zheng, Z Hong, H Wang, Y Wang, M Li… - Journal of Integrative …, 2021 - Elsevier
Objective Ganoderma lucidum spore (GLS) is gaining recognition as a medicinal part of G.
lucidum and has been reported to possess various pharmacological properties, such as …

Ganoderma sinense polysaccharide: An adjunctive drug used for cancer treatment

Y Zhang, Y Jiang, M Zhang, L Zhang - Progress in Molecular Biology and …, 2019 - Elsevier
Ganoderma sinense is one of well-known herb medicine and has been used for 2000 years
in China. G. lucidum and G. sinense are two family members of Ganoderma, a genus of …