Circular RNA: an emerging non-coding RNA as a regulator and biomarker in cancer

B Chen, S Huang - Cancer letters, 2018 - Elsevier
Circular RNA (circRNA) is a type of covalently closed non-coding RNA that may regulate
gene expression in eukaryotes. The recent application of high-throughput RNA sequencing …

Circular RNAs: biogenesis, function and role in human diseases

J Greene, AM Baird, L Brady, M Lim… - Frontiers in molecular …, 2017 - frontiersin.org
Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike
linear RNAs, form covalently closed continuous loops and act as gene regulators in …

Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression

J Wei, M Li, C Xue, S Chen, L Zheng, H Deng… - Journal of Experimental …, 2023 - Springer
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …

Cancer-related circular RNA: diverse biological functions

D Cheng, J Wang, Z Dong, X Li - Cancer cell international, 2021 - Springer
Noncoding RNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and
circular RNAs (circRNAs), are involved in regulating biological functions. In recent decades …

Accentuating CircRNA-miRNA-transcription factors axis: a conundrum in cancer research

D Singh, P Kesharwani, NA Alhakamy… - Frontiers in …, 2022 - frontiersin.org
Circular RNAs (circRNAs) are the newly uncovered class of non-coding RNAs being
cognized as profound regulators of gene expression in developmental and disease biology …

CircRNA: a novel type of biomarker for cancer

H Zhang, L Jiang, D Sun, J Hou, Z Ji - Breast cancer, 2018 - Springer
Circular RNAs (circRNAs) are a class of long, non-coding RNAs molecules that shape a
covalently closed continuous loop which have no 5′–3′ polarity and contain no polyA tail …

Function and clinical significance of circRNAs in solid tumors

Y Geng, J Jiang, C Wu - Journal of hematology & oncology, 2018 - Springer
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA
regulates gene expression in many biological processes, and it also participates in the …

Mechanisms regulating abnormal circular RNA biogenesis in cancer

Y Huang, Q Zhu - Cancers, 2021 - mdpi.com
Simple Summary Circular RNAs (circRNAs) are circular RNA molecules without a 5′ cap
and a 3′ poly (A) tail structure, which play an important role in tumor development, invasion …

Circular RNAs (circRNAs) in cancer

R Zhou, Y Wu, W Wang, W Su, Y Liu, Y Wang, C Fan… - Cancer letters, 2018 - Elsevier
Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5′ end caps or
3′ end poly (A) tails. There are more than one hundred thousand genes that encode …

Circular RNA: metabolism, functions and interactions with proteins

WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …