Background Androgen ablation therapy is the primary treatment for metastatic prostate
cancer (PCa). However, the majority of PCa patients receiving the androgen deprivation …

Background More than 80% of advanced prostate cancer (PCa) cases have bone
metastasis, with a 5-year survival rate of 25%. Previously, we reported that GRT, a …

Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patients
with metastatic castration-resistant prostate cancer (CRPC). However, patients receiving …

Zanthoxyli Fructus belongs to the family of oranges and is used as a seasoning in Asian
countries including Japan. This study found that a water extract of Zanthoxyli Fructus …

Castration-resistant prostate cancer (CRPC) is an advanced form of prostate cancer
associated with poor survival rates. The high proliferation and metastasis rates have made …

Carvacrol, a major monoterpenoid phenol from Origanum and Thymus species, has been
shown to exhibit antiproliferative and anticancer properties in a few recent studies …

Background Resveratrol is reported to inhibit the growth of prostate, which is characteristic of
benign prostatic hyperplasia (BPH) condition. However, the mechanism remains unclear …

Background The development of potent non-toxic chemotherapeutic drugs against
castration resistant prostate cancer (CRPC) remains a major challenge. Corosolic acid (CA) …

Background Resveratrol, a naturally occurring phytopolyphenol compound, has attracted
extensive interest in recent years because of its diverse pharmacological characteristics …

The protein kinase Akt plays an important role in cell proliferation and survival in many
cancers, including prostate cancer. Due to its kinase activity, it serves as a molecular conduit …