The yin and yang of nitric oxide in cancer progression

AJ Burke, FJ Sullivan, FJ Giles, SA Glynn - Carcinogenesis, 2013 - academic.oup.com
Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions
in the body. Presently, there are markedly conflicting findings in the literature regarding NO …

The regulation of nitric oxide in tumor progression and therapy

Y Hu, J Xiang, L Su, X Tang - Journal of International …, 2020 - journals.sagepub.com
Nitric oxide (NO) is a ubiquitous gas with free radical groups that is soluble in water, and
which is involved in numerous physiological functions including inflammatory and immune …

Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities

S Mocellin, V Bronte, D Nitti - Medicinal research reviews, 2007 - Wiley Online Library
Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

Regulation of pleiotropic physiological roles of nitric oxide signaling

L Soundararajan, A Dharmarajan, P Samji - Cellular signalling, 2023 - Elsevier
Nitric Oxide (NO) is a highly diffusible, ubiquitous signaling molecule and a free radical that
is naturally synthesized by our body. The pleiotropic effects of NO in biological systems are …

Nitric oxide—a novel therapeutic for cancer

JA Coulter, HO McCarthy, J Xiang, W Roedl, E Wagner… - Nitric oxide, 2008 - Elsevier
Much research over the past two decades has focussed on understanding the complex
interactions of nitric oxide (NO) in both physiological and pathological processes. As with …

Nitric oxide and cancer therapy: the emperor has NO clothes

JR Hickok, DD Thomas - Current pharmaceutical design, 2010 - ingentaconnect.com
The role of nitric oxide (NO•) as a mediator of cancer phenotype has led researchers to
investigate strategies for manipulating in vivo production and exogenous delivery of this …

Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies

S Singh, AK Gupta - Cancer chemotherapy and pharmacology, 2011 - Springer
Purpose The diatomic radical nitric oxide (NO) has been the cause of intense debate with
implication in carcinogenesis, tumour progression, invasion, angiogenesis and modulation …

Targeting nitric oxide for cancer therapy

D Hirst, T Robson - Journal of Pharmacy and Pharmacology, 2007 - Wiley Online Library
A blueprint for the ideal anticancer molecule would include most of the properties of nitric
oxide (NO•), but the ability to exploit these characteristics in a therapeutic setting requires a …

[HTML][HTML] Nitric oxide and cancer: a review

S Korde Choudhari, M Chaudhary, S Bagde… - World journal of surgical …, 2013 - Springer
Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in
various physiological as well as pathological processes. Over past decades, NO has …

The role of nitric oxide in tumour progression

D Fukumura, S Kashiwagi, RK Jain - Nature Reviews Cancer, 2006 - nature.com
Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …