Resistance to current therapeutic interventions is a major challenge in the treatment of
patients affected by cancer. While nitric oxide (NO) might have proneoplastic properties, it is …

Angiogenesis, the development of new capillaries form pre-existing vessels, requires the
coordinate activation of endothelial cells, which migrate and proliferate in response to …

Inducible nitric oxide (NO) synthase (NOS) II has been implicated in macrophage-mediated
antitumor activity. However, use of the NOS II gene in cancer therapy is problematic because …

In recent years, several novel approaches have been developed to overcome tumor cell
resistance to conventional therapeutics. Such approaches include genetic manipulations …

Altered metabolic phenotype has been recognized as a hallmark of tumor cells for many
years, but this aspect of the cancer phenotype has come into greater focus in recent years …

Nitric oxide (NO) is a ubiquitous, endogenously produced, water-soluble signaling molecule
playing critical roles in physiological processes. Nitric oxide plays pleiotropic roles in cancer …

Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse
and often opposing biological activities. The diversity in response to this simple diatomic …

Purpose: Aberrant expression of inflammatory molecules, such as inducible nitric oxide (NO)
synthase (iNOS), has been linked to cancer, suggesting that their inhibition is a rational …

Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Recent literature
indicates that endothelial NO synthase (eNOS) can modulate cancer-related events …

Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …