Alzheimer's disease (AD) is a devastating progressive neurodegenerative disease
characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron …

Iron plays a crucial role in many physiological processes of the human body, but iron is
continuously deposited in the brain as we age. Early studies found iron overload is directly …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Neurodegeneration is a multifactorial process that involves multiple mechanisms. Examples
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …

Iron is an essential transition metal for numerous biologic processes in mammals. Iron
metabolism is regulated via several coordination mechanisms including absorption …

Alzheimer's disease is an emerging global epidemic that is becoming increasingly
unsustainable. Most of the clinical trials have been centered around targeting β-amyloid and …

Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is
attributed to its interactions with the central proteins of AD pathology (amyloid precursor …

In the development of Alzheimer's disease (AD), cell death is common. Novel cell death form—
ferroptosis is discovered in recent years. Ferroptosis is an iron-regulated programmed cell …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …