The viral lytic cycle is an important process in oncolytic virotherapy. Most mathematical
models for oncolytic virotherapy do not incorporate this process. In this article, we propose a …

Cancer is a common term for many diseases that can affect anybody. A worldwide leading
cause of death is cancer, according to the World Health Organization (WHO) report. In 2020 …

Oncolytic (cancer-killing) virus treatment is a promising new therapy for cancer, with many
viruses currently being tested for their ability to eradicate tumors. One of the major stumbling …

Oncolytic virotherapy (OV) is a cancer therapy utilizing lytic viruses that specifically target
cancer cells for elimination. In this relatively new therapy, two contradictory observations …

The use of viruses as a cancer treatment is becoming increasingly more robust; however,
there is still a long way to go before a completely successful treatment is formulated. One …

The complexity of the immune responses is a major challenge in current virotherapy. This
study incorporates the innate immune response into our basic model for virotherapy and …

Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-
cancer immune responses, has garnered significant attention in recent years. In our …

A mathematical model of tumor-immune system interactions with an oncolytic virus therapy
for which the immune system plays a twofold role against cancer cells is derived. The …

Resistance to treatment poses a major challenge for cancer therapy, and oncoviral treatment
encounters the issue of viral resistance as well. In this investigation, we introduce …

In this paper, we present a computational mathematical model to investigate the efficacy of
tumor virotherapy using oncolytic viruses. A numerical algorithm, which is stable and second …