We propose an extension of a standard stochastic individual-based model in population
dynamics which broadens the range of biological applications. Our primary motivation is …

A mathematical model of tumor-immune system interactions with an oncolytic virus therapy
for which the immune system plays a twofold role against cancer cells is derived. The …

Oncolytic viruses (OVs) exploit characteristics of mass cells and tumor-related reaction of the
body to the presence of antigen, to lyse malignant cells and modulate the tumor …

Oncolytic virotherapy is a promising cancer treatment that uses replication-competent
viruses to target and kill tumor cells. Oncolytic alphavirus M1 is a naturally occurring virus …

Oncolytic virotherapy—the use of viruses that specifically kill tumor cells—is an innovative
and highly promising route for treating cancer. However, its therapeutic outcomes are mainly …

Virotherapy is a novel treatment for cancer, which may be delivered as a single agent or in
combination with other therapies. Research studies indicated that the combination of viral …

Combining chimeric antigen receptor T (CAR-T) cells with oncolytic viruses (OVs) has
recently emerged as a promising treatment approach in preclinical studies that aim to …

Background Anti-tumor therapies aim at reducing to zero the number of tumor cells in a host
within their end or, at least, aim at leaving the patient with a sufficiently small number of …

Great attention has been paid to cancer therapy by means of oncolytic viruses, but the fast
virus-spread, which eliminates all tumor cells, cannot be applied to solid tumors. As slow …

Replicating oncolytic viruses are able to infect and lyse cancer cells and spread through the
tumor, while leaving normal cells largely unharmed. This makes them potentially useful in …