The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate
G Van den Mooter - Drug Discovery Today: Technologies, 2012 - Elsevier
The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …
Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development
R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …
absorption leading to poor bioavailability. Several approaches exist that improve the oral …
Amorphous solid dispersion technique for improved drug delivery: basics to clinical applications
Solid dispersion has emerged as a method of choice and has been extensively investigated
to ascertain the in vivo improved performance of many drug formulations. It generally …
to ascertain the in vivo improved performance of many drug formulations. It generally …
Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
The need for restructuring the disordered science of amorphous drug formulations
K Edueng, D Mahlin, CAS Bergström - Pharmaceutical research, 2017 - Springer
The alarming numbers of poorly soluble discovery compounds have centered the efforts
towards finding strategies to improve the solubility. One of the attractive approaches to …
towards finding strategies to improve the solubility. One of the attractive approaches to …
Amorphous drugs and dosage forms
H Grohganz, K Löbmann, P Priemel, KT Jensen… - Journal of Drug Delivery …, 2013 - Elsevier
The transformation to an amorphous form is one of the most promising approaches to
address the low solubility of drug compounds, the latter being an increasing challenge in the …
address the low solubility of drug compounds, the latter being an increasing challenge in the …
Refining stability and dissolution rate of amorphous drug formulations
H Grohganz, PA Priemel, K Löbmann… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of
the main challenges in the development of new small molecular drugs. Additionally, the …
the main challenges in the development of new small molecular drugs. Additionally, the …
Characterization of amorphous solid dispersions: An update
X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …
Amorphous solid dispersion method for improving oral bioavailability of poorly water-soluble drugs
S Gurunath, SP Kumar, NK Basavaraj… - journal of pharmacy …, 2013 - Elsevier
Amorphous solid dispersions are one of the most promising strategies to improve the oral
bioavailability of sparingly water-soluble drugs. Drug particle size reduction improved the …
bioavailability of sparingly water-soluble drugs. Drug particle size reduction improved the …
Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery
The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …
However, due to thermodynamic instability and recrystallization tendencies during …