Purpose Umbelliferone (Umb), a member of coumarin family, is found in many plants and is
a promising molecule with potential anti-inflammatory, anti-oxidative, and anti-tumor …

Umbelliferone (UMB), a natural coumarin compound, has been reported to possess anti-
rheumatic effects on rheumatoid arthritis (RA) experimental models, but its potential role of …

Osteoclasts, bone-resorbing somatic cells, are directly responsible for bone destruction
during rheumatoid arthritis. Complete Freund adjuvant (CFA) is a widely used animal model …

Nimbolide is an active constituent of Azadirachta indica and is known for its anti‐
inflammatory, anti‐oxidant, immune‐modulatory, and anti‐cancer effects. Few studies …

Abstract Aim Activation of transmembrane Notch-1 receptors through inflammatory cytokines
is highly regulated by STAT-3 and NF-κB phosphorylation. Nimbolide (NMB) exhibits potent …

Rheumatoid arthritis (RA) severely affects the quality life of patients due to its high
association with disability. Traditional Chinese medicines have been reported to exert …

To evaluate the effect of apigenin (AP) on arthritis in rats stimulated by Freund's complete
adjuvant (FCA) was the main purpose of the investigation. Arthritis model was established …

Rheumatoid arthritis (RA) is a chronic and accelerated autoimmune illness with proliferative
and damaging synovitis, resulting in joint death and cartilage and bone erosion. This study …

Background Genkwanin is a flavone isolated from the traditional Chinese herb Daphne
genkwa. Our previous work proved that four flavonoids (including genkwanin) isolated from …

Naringin (COG) is a flavanone with various bioactivities including an expectorant effect,
antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the …