Aims Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its pathological features
are synovial inflammation, bone erosion, and joint structural damages. Our previous studies …

Thymoquinone, an active ingredient isolated from Nigella sativa, has been reported to have
anti-inflammatory effects. However, the anti-inflammatory effect of thymoquinone on IL-1β …

Mulberry leaf has been traditionally used to treat chronic diseases such as diabetes and
cancer. The effect and mechanism of mulberry leaf extract (MLE) in LPS-induced activation …

Abstract Objective. Emodin (3-methyl-1, 6, 8-trihydroxyanthraquinone) is one of the active
components present in the root and rhizome of Rheum palmatum. It has been shown to …

Inhibition of over‑activated inflammation has been demonstrated as one of the most efficient
strategies for treating inflammatory diseases. In the present study, 6‑formyl umbelliferone …

Sweroside (SW), as a bioactive herbal ingredient, has anti-inflammatory effects. Protective
effects of SW on IL-1β-stimulated articular chondrocytes, however, has not been fully …

The nuclear factor erythroid 2-related factor (Nrf2) signaling pathway has recently emerged
as a novel therapeutic target in treating various diseases. Therefore, the present study …

Here, we investigated the anti-inflammatory activity of lucidone, a phytocompound isolated
from the fruits of Lindera erythrocarpa Makino, against lipopolysaccharide (LPS)-induced …

Objectives: Nuclear factor kappa B (NF-κB) is a major regulator of pivotal proinflammatory
cytokines in the pathogenesis of rheumatoid arthritis (RA). Bortezomib inhibits NF-κB …

Dexamethasone (Dex) exhibits broad-spectrum anti-inflammatory effects in chronic
destructive rheumatoid arthritis. We present in vivo and in vitro evidence supporting the …