During an induced immune response, the BALB/c strain of laboratory mouse presents
ovalbumin peptides by major histocompatibility complexes that stimulate responding T cells …

T cell activation requires formation of a tri-molecular interaction between a major
histocompatibility complex (MHC), peptide, and T cell receptor. In a common model system …

Proteins of the class II major histocompatibility complex (MHC) bind antigenic peptides that
are subsequently presented to T cells. Previous studies have shown that most of the …

The identification of food allergen T-cell epitopes provides a platform for the development of
novel immunotherapies. Despite extensive knowledge of the physicochemical properties of …

Class I molecules are conformationally sensitive to peptide binding, prolonging the
complex's half-life on the surface of the cell. By making a series of H2 Kb anchor motif …

Priming C57BL/6 mice with dominant antigenic peptides of ovalbumin (OVA) or bovine
insulin (INS) in complete Freund's adjuvant generates antigen-specific, H-2Kb-restricted …

Intracellular trafficking of major histocompatibility complex (MHC) class II molecules is
characterized by passage through specialized endocytic compartment (s) where antigenic …

We have analyzed the T cell receptor (TCR) repertoire found in the major histocompatibility
complex class I‐restricted cytotoxic T lymphocyte (CTL) response to the protein ovalbumin …

Major histocompatibility complex class I molecules can be expressed as single polypeptides
wherein the antigenic peptide, β 2-microglobulin, and heavy chain are attached by flexible …

The ability of the immune system to focus T cell responses against a select number of
potential epitopes of a complex antigen is termed immunodominance. Epitopes that trigger …