A combined preclinical therapy of cannabinoids and temozolomide against glioma

S Torres, M Lorente, F Rodríguez-Fornés… - Molecular cancer …, 2011 - AACR
Glioblastoma multiforme (GBM) is highly resistant to current anticancer treatments, which
makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of …

Optimization of a preclinical therapy of cannabinoids in combination with temozolomide against glioma

I López-Valero, S Torres, M Salazar-Roa… - Biochemical …, 2018 - Elsevier
Glioblastoma multiforme (GBM) is the most frequent and aggressive form of brain cancer.
These features are explained at least in part by the high resistance exhibited by these …

[HTML][HTML] Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide

I López-Valero, C Saiz-Ladera, S Torres… - Biochemical …, 2018 - Elsevier
Glioblastoma multiforme (GBM) is the most frequent and aggressive type of brain tumor due,
at least in part, to its poor response to current anticancer treatments. These features could be …

Cannabinoids in glioblastoma therapy: new applications for old drugs

CA Dumitru, IE Sandalcioglu, M Karsak - Frontiers in molecular …, 2018 - frontiersin.org
Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of
solid cancer overall. Despite aggressive therapeutic approaches consisting of maximum …

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

KA Scott, AG Dalgleish, WM Liu - Molecular cancer therapeutics, 2014 - AACR
High-grade glioma is one of the most aggressive cancers in adult humans and long-term
survival rates are very low as standard treatments for glioma remain largely unsuccessful …

Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor …

A Ellert-Miklaszewska, IA Ciechomska, B Kaminska - Cancers, 2021 - mdpi.com
Simple Summary Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic
defects in TP53 and PTEN tumor suppressor genes, which render tumors refractory to …

Cannabinoids and gliomas

G Velasco, A Carracedo, C Blázquez, M Lorente… - Molecular …, 2007 - Springer
Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking
endogenous substances—the endocannabinoids—that activate specific cell surface …

Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

SDM Allister, C Chan, RJ Taft, T Luu, ME Abood… - Journal of neuro …, 2005 - Springer
Normal tissue toxicity limits the efficacy of current treatment modalities for glioblastoma
multiforme (GBM). We evaluated the influence of cannabinoids on cell proliferation, death …

Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor …

L Deng, L Ng, T Ozawa, N Stella - Journal of Pharmacology and …, 2017 - ASPET
Evidence suggests that the nonpsychotropic cannabis-derived compound, cannabidiol
(CBD), has antineoplastic activity in multiple types of cancers, including glioblastoma …

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines

P Massi, A Vaccani, S Ceruti, A Colombo… - … of Pharmacology and …, 2004 - ASPET
Recently, cannabinoids (CBs) have been shown to possess antitumor properties. Because
the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the …