[HTML][HTML] Delivery systems for siRNA drug development in cancer therapy
C Xu, J Wang - Asian Journal of Pharmaceutical Sciences, 2015 - Elsevier
Since the discovery of the Nobel prize-winning mechanism of RNA interference (RNAi) ten
years ago, it has become a promising drug target for the treatment of multiple diseases …
years ago, it has become a promising drug target for the treatment of multiple diseases …
siRNA delivery systems for cancer treatment
YK Oh, TG Park - Advanced drug delivery reviews, 2009 - Elsevier
With increasing knowledge on the molecular mechanisms of endogenous RNA interference,
small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines …
small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines …
siRNA based drug design, quality, delivery and clinical translation
MA Subhan, VP Torchilin - Nanomedicine: Nanotechnology, Biology and …, 2020 - Elsevier
Gene silencing by RNA interference represents a promising therapeutic approach. The
development of carriers, eg, polymers, lipids, peptides, antibodies, aptamers, small …
development of carriers, eg, polymers, lipids, peptides, antibodies, aptamers, small …
Recent progress in development of siRNA delivery vehicles for cancer therapy
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
A review of the current status of siRNA nanomedicines in the treatment of cancer
P Resnier, T Montier, V Mathieu, JP Benoit, C Passirani - Biomaterials, 2013 - Elsevier
RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …
[HTML][HTML] Nano-formulated siRNA-based therapeutic approaches for cancer therapy
D Jain, SK Prajapati, A Jain, R Singhal - Nano Trends, 2023 - Elsevier
RNAi is a remarkable treatment strategy to knock down gene overexpression in a variety of
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …
Strategies, design, and chemistry in siRNA delivery systems
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
[HTML][HTML] Molecularly engineered siRNA conjugates for tumor-targeted RNAi therapy
RNA interference (RNAi) is a major cellular mechanism regulating gene expression in which
short double-stranded RNA molecules called small interfering RNA (siRNA) mediate …
short double-stranded RNA molecules called small interfering RNA (siRNA) mediate …
siRNA applications in nanomedicine
T Tokatlian, T Segura - Wiley Interdisciplinary Reviews …, 2010 - Wiley Online Library
The ability to specifically silence genes using RNA interference (RNAi) has wide therapeutic
applications for the treatment of disease or the augmentation of tissue formation. RNAi is the …
applications for the treatment of disease or the augmentation of tissue formation. RNAi is the …
Advances in siRNA delivery strategies for the treatment of MDR cancer
RNA interference (RNAi) represents a promising therapeutic method that uses siRNA for
cancer treatment. Although the RNAi technique has been increasingly used for clinical trials …
cancer treatment. Although the RNAi technique has been increasingly used for clinical trials …