Background Obesity invokes a range of metabolic disturbances, but the transition from a
poor to excessive nutritional environment may exacerbate adult metabolic dysfunction. The …

Aim To determine whether late gestation under‐and overnutrition programme metabolic
plasticity in a similar way, and whether metabolic responses to an obesogenic diet in early …

Aim To investigate if late gestation under‐or overnutrition has similar adverse impacts on
visceral adiposity, metabolic and endocrine function in sheep, and if subsequent exposure …

Epidemiological and experimental studies suggest early nutrition has long-term effects on
susceptibility to obesity, cardiovascular and metabolic diseases. Small and large animal …

We aimed to investigate whether over-versus undernutrition in late foetal life combined with
obesity development in early postnatal life have differential implications for fat distribution …

The early-life environment has implications for risk of adult-onset diseases, such as glucose
intolerance, insulin insensitivity, and obesity, effects that may occur with or without reduced …

Aim Exposure to adverse intra‐uterine conditions can predispose for metabolic disorders
later in life. By using a sheep model, we studied (i) how programming of glucose–insulin …

Maternal undernutrition increases the risk of type 2 diabetes and metabolic syndrome later
in life, particularly upon postnatal exposure to a high-energy diet. However, dysfunctions of …

We have developed a sheep model to facilitate studies of the fetal programming effects of
mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty …

We previously reported that maternal overnutrition and obesity (MO) throughout pregnancy
and lactation in sheep (MOF0) decreases term fetal pancreatic β-cell numbers and …