Dr Eric Topol, Cleveland Clinic, Cleveland, Ohio, presented the third Global Use of
STrategies to Open occluded coronary arteries (GUSTO III) study. This was a randomized …

Thrombolytic therapy remains a mainstay for the treatment of patients with acute myocardial
infarction. This therapy has been the subject of intense investigation and multiple studies as …

Results of multiple studies have amply verified the benefit of urgent coronary
revascularization for patients who have acute myocardial infarction (MI). Currently …

Background In the randomized Global Utilization of t-PA and Streptokinase for Occluded
Coronary Arteries (GUSTO-I) trial, 41 021 patients received one of four thrombolytic …

Abstract The Global Utilization of Streptokinase and Tissue Plasminogen Activator for
Occluded Coronary Arteries (GUSTO) trial is a large scale international trial of new …

The primary success rate for angioplasty of total occlusions is significantly worse than for
subtotal lesions. Pharmacologic recanalization of total occlusions before angioplasty has the …

The insights from the Global Utilization of Streptokinase and t-PA for Occluded Arteries
(GUSTO) trial have paved the way for further refinement in myocardial reperfusion …

To determine the clinical profile and efficacy of accelerated recombinant tissue-type
plasminogen activator (rt-PA) dose regimens, five different strategies of thrombolytic therapy …

Background Among physicians who treat patients with acute myocardial infarction, there is
controversy about the magnitude of the clinical benefit of primary (ie, immediate) coronary …

Intuitively, one would assume that the benefit from the use of thrombolytic therapy in
reducing mortality in acute myocardial infarction (AMI) is directly related to early …