Molecular architecture of the Cryptococcus neoformans capsule

MA Gates, P Thorkildson, TR Kozel - Molecular microbiology, 2004 - Wiley Online Library
Many microbes are surrounded by phagocytosis‐inhibiting capsules. We took advantage of
the large size of the polysaccharide capsule of the pathogenic yeast Cryptococcus …

Capsules from Pathogenic and Non-Pathogenic Cryptococcus spp. Manifest Significant Differences in Structure and Ability to Protect against Phagocytic Cells

GS Araujo, FL Fonseca, B Pontes, A Torres… - PloS one, 2012 - journals.plos.org
Capsule production is common among bacterial species, but relatively rare in eukaryotic
microorganisms. Members of the fungal Cryptococcus genus are known to produce …

Capsule of Cryptococcus neoformans grows by enlargement of polysaccharide molecules

S Frases, B Pontes, L Nimrichter… - Proceedings of the …, 2009 - National Acad Sciences
The human pathogenic fungus Cryptococcus neoformans has a distinctive polysaccharide
(PS) capsule that enlarges during infection. The capsule is essential for virulence, but the …

Cryptococcus neoformans capsule regrowth experiments reveal dynamics of enlargement and architecture

MP Wear, E Jacobs, S Wang, SA McConnell… - Journal of Biological …, 2022 - ASBMB
The polysaccharide capsule of fungal pathogen Cryptococcus neoformans is a critical
virulence factor that has historically evaded complete characterization. Cryptococcal …

A Yeast under Cover: the Capsule of Cryptococcus neoformans

I Bose, AJ Reese, JJ Ory, G Janbon, TL Doering - Eukaryotic cell, 2003 - Am Soc Microbiol
Few fungi are pathogenic to humans. Of these, Cryptococcus neoformans has emerged as
an important cause of mortality in immunocompromised patients, especially those with AIDS …

Cryptococcus neoformans capsule biosynthesis and regulation

G Janbon - FEMS yeast research, 2004 - academic.oup.com
The capsule is certainly the most prominent virulence factor in Cryptococcus neoformans:
acapsular strains are avirulent, and capsular polysaccharides have a deleterious effect on …

The capsule of Cryptococcus neoformans

A Casadevall, C Coelho, RJB Cordero, Q Dragotakes… - Virulence, 2019 - Taylor & Francis
The capsule of Cryptococcus neoformans is its dominant virulence factor and plays a key
role in the biology of this fungus. In this essay, we focus on the capsule as a cellular …

The polysaccharide capsule of the pathogenic fungus Cryptococcus neoformans enlarges by distal growth and is rearranged during budding

O Zaragoza, A Telzak, RA Bryan… - Molecular …, 2006 - Wiley Online Library
The capsule of Cryptococcus neoformans can undergo dramatic enlargement, a
phenomenon associated with virulence. A prior study that used Ab to the capsule as a …

[PDF][PDF] Dismantling the Cryptococcus coat

CA D'Souza, J Heitman - Trends in microbiology, 2001 - Citeseer
Cryptococcus neoformans is an encapsulated yeast and an opportunistic fungal pathogen
responsible for lifethreatening infections of the central nervous system (CNS) in HIV-1 …

Complementation of a Capsule-Deficient Mutation of Cryptococcus neoformans Restores its Virulence

YC Chang, KJ Kwon-Chung - Molecular and cellular biology, 1994 - Taylor & Francis
Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans.
To study the molecular basis of capsule synthesis, the capsule-deficient phenotype of a …