Targeting hypoxia-inducible factor-1α/pyruvate dehydrogenase kinase 1 axis by dichloroacetate suppresses bleomycin-induced pulmonary fibrosis
Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly
activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how …
activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how …
Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis
Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
[HTML][HTML] Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis
Z Wang, L Chen, Y Huang, M Luo, H Wang, Z Jiang… - Redox Biology, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically …
matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically …
Metabolic reprogramming of pulmonary fibrosis
J Li, X Zhai, X Sun, S Cao, Q Yuan… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …
Metabolic reprogramming as a driver of fibroblast activation in pulmonaryfibrosis
Pulmonary fibrosis refers to a heterogeneous group of disorders that scar the lung, most
often irreversibly. To date, there are limited effective treatments for these conditions, despite …
often irreversibly. To date, there are limited effective treatments for these conditions, despite …
Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis
A Aquino-Gálvez, G González-Ávila… - Respiratory …, 2019 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is an age-related, progressive and lethal
disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce …
disease, whose pathogenesis is associated with fibroblasts/myofibroblasts foci that produce …
Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
E Schruf, V Schroeder, CA Kuttruff, S Weigle, M Krell… - Respiratory …, 2019 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized
by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though …
by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though …
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis
B Selvarajah, I Azuelos, D Anastasiou… - Science Signaling, 2021 - science.org
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis
Metabolic reprogramming has been intrinsically linked to macrophage activation. Alveolar
macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis …
macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis …
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism
RB Hamanaka, GM Mutlu - The FEBS journal, 2021 - Wiley Online Library
Fibrosis is a pathologic condition characterized by excessive deposition of extracellular
matrix and chronic scaring that can affect every organ system. Organ fibrosis is associated …
matrix and chronic scaring that can affect every organ system. Organ fibrosis is associated …