Fibrosis is a pathologic condition characterized by excessive deposition of extracellular
matrix and chronic scaring that can affect every organ system. Organ fibrosis is associated …

Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with
unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the normal alveolar network is
gradually replaced by fibrotic scars. Current evidence suggests that metabolic alterations …

Abnormal repair and dysregulated angiogenesis have been implicated in the pathogenesis
of pulmonary fibrosis, but the underlying mechanisms of regulation are not well understood …

The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by interstitial
remodeling and pulmonary dysfunction. The etiology of IPF is not completely understood but …

Fibroblast activation is transient in successful wound repair but persistent in fibrotic
pathologies. Understanding fibroblast deactivation during successful wound healing may …

Metabolic dysregulation in fibroblasts is implicated in the profibrotic actions of transforming
growth factor–β (TGF-β). Here, we present evidence that hexokinase 2 (HK2) is important for …

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive pulmonary scarring,
decline in lung function, and often results in death within 3–5 five years after diagnosis …