Aging increases oxidative stress and osteoblast apoptosis and decreases bone mass,
whereas forkhead box O (FoxO) transcription factors defend against oxidative stress by …

Osteoporosis, a disease of low bone mass, is associated with decreased osteoblast
numbers and increased levels of oxidative stress within osteoblasts. Since transcription …

The FoxO subfamily of forkhead transcription factors plays a critical role in a variety of
physiological processes including metabolism, differentiation, proliferation, apoptosis and …

Reactive oxygen species (ROS) and cellular oxidative stress are involved in many
physiological and pathophysiological processes, including cellular and organismal aging …

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species
(ROS) play an important role in physiological intracellular signalling by triggering …

Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1,
FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes …

Several pathologies such as neurodegeneration and cancer are associated with aging,
which is affected by many genetic and environmental factors. Healthy aging conceives …

Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved
transcription factors for their highly conserved DNA-binding domain. In mammalian species …

Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to
stimulation by bone morphogenetic proteins. Studies presented here examined the …

The FoxO family of forkhead transcription factors is at the crossroads of many signal
transduction pathways that are evolutionarily conserved. Such pathways have been co …