Cdc20: a WD40 activator for a cell cycle degradation machine

H Yu - Molecular cell, 2007 - cell.com
Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms
from yeast to man and contains at its C terminus a WD40 repeat domain that mediates …

Dephosphorylation of Cdc20 is required for its C‐box‐dependent activation of the APC/C

H Labit, K Fujimitsu, NS Bayin, T Takaki… - The EMBO …, 2012 - embopress.org
The anaphase‐promoting complex/cyclosome (APC/C) ubiquitin ligase is tightly regulated to
ensure programmed proteolysis in cells. The activity of the APC/C is positively controlled by …

Cdc20: at the crossroads between chromosome segregation and mitotic exit

M Kapanidou, NL Curtis, VM Bolanos-Garcia - Trends in biochemical …, 2017 - cell.com
Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome
segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) …

[HTML][HTML] The regulation of Cdc20 proteolysis reveals a role for the APC components Cdc23 and Cdc27 during S phase and early mitosis

S Prinz, ES Hwang, R Visintin, A Amon - Current Biology, 1998 - cell.com
Background: In eukaryotic cells, a specialized proteolysis machinery that targets proteins
containing destruction-box sequences for degradation and that uses a ubiquitin ligase …

Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint

Y Yudkovsky, M Shteinberg, T Listovsky… - Biochemical and …, 2000 - Elsevier
The cyclosome/anaphase promoting complex (APC) is a multisubunit ubiquitin ligase that
targets mitotic regulators for degradation in exit from mitosis. It is activated at the end of …

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

W Tian, B Li, R Warrington… - Proceedings of the …, 2012 - National Acad Sciences
The anaphase-promoting complex/cyclosome (APC/C) promotes anaphase onset and
mitotic exit through ubiquitinating securin and cyclin B1. The mitotic APC/C activator, the cell …

Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells

MJ Kallio, VA Beardmore, J Weinstein… - The Journal of cell …, 2002 - rupress.org
Cdc20 is a substrate adaptor and activator of the anaphase-promoting complex/cyclosome
(APC/C), the E3 ubiquitin ligase whose activity is required for anaphase onset and exit from …

Cell cycle–and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1

BO Petersen, C Wagener, F Marinoni… - Genes & …, 2000 - genesdev.cshlp.org
CDC6 is conserved during evolution and is essential and limiting for the initiation of
eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and …

How APC/C–Cdc20 changes its substrate specificity in mitosis

D Izawa, J Pines - Nature cell biology, 2011 - nature.com
Progress through mitosis requires that the right protein be degraded at the right time. One
ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) targets most of the …

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos

M Li, JP York, P Zhang - Molecular and cellular biology, 2007 - Am Soc Microbiol
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase mediating
targeted proteolysis through ubiquitination of protein substrates to control the progression of …