A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These
compounds constitute a systematic series of molecules with a progressive increase in affinity …

In recent years it has become apparent that protein tyrosine kinases (PTKs) mediate
proliferative signals as well as metabolic signals. 1 This realization promoted the hypothesis …

Publisher Summary This chapter discusses the inhibition of protein-tyrosine kinases by
tyrphostins. Many protein tyrosine kinases (PTKs) catalyze the phosphorylation of tyrosine …

A series of the synthetic protein tyrosine kinase inhibitors known as tyrphostins were studied
for their effect on insulin-like growth factor-1 and insulin-stimulated cellular proliferation on …

Synthetic compounds called tyrphostins were examined for their effects on cells which are
mitogenically responsive to epidermal growth factor (EGF). We studied in detail the effects of …

Protein tyrosine kinases (PTKs) are members of a growing family of oncoproteins and
protooncoproteins that play a pivotal role in normal and abnormal proliferative processes …

Many human tumors of epithelial origin contain cells overexpressing the epidermal growth
factor (EGF) receptor, and there is convincing evidence that cancer cell growth is correlated …

Revised Manuscript Received February 2, 1993 abstract: A series of the synthetic protein
kinase inhibitors known as tyrphostins were examined for their effects on the tyrosine …

A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-
arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor …

H~NN JR Page 1 Pergamon Bioorganic & Medicinal Chemistry, Vol. 4, No. 8, pp 1203-1207,
1996 Copyright © 1996 Elsevier Science Ltd Printed in Great Britain. All rights reserved PII …