In T-cell biology,'exhaustion'was initially described as a hyporesponsive state in CD8+ T
cells during chronic infections. Recently, exhaustion has been recognized as a T-cell …

T-cell exhaustion was originally identified during chronic infection in mice, and was
subsequently observed in humans with cancer. The exhausted T cells in the tumor …

CD8+ T cells are essential lymphocytes with cytotoxic properties for antitumor
immunotherapy. However, during chronic infection or tumorigenesis, these cells often …

CD8+ T cell exhaustion is a stable dysfunctional state driven by chronic antigen stimulation
in the tumor microenvironment (TME). Differentiation of exhausted CD8+ T cells (CD8+ …

The persistent antigen stimulation during chronic infections and cancer results in CD8+ T
cell exhaustion. The exhausted T (Tex) cells within the tumor microenvironment (TME) are …

Simple Summary It has been known for decades that immune T cells, especially due to their
capacity for powerful antigen-directed cytotoxicity, have become a central focus for engaging …

Tumor-specific CD8+ T cells are exposed to persistent antigenic stimulation which induces a
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …

In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …

CD8+ T cells play a crucial role in anti‐tumour immunity, but they often undergo exhaustion,
which affects the anti‐tumour activity of CD8+ T cells. The effect and mechanism of …

The immune system is capable of distinguishing between danger-and non-danger signals,
thus inducing either an appropriate immune response against pathogens and cancer or …