Metabolic and Hemodynamic Events after Changes in Neuronal Activity: Current Hypotheses, Theoretical Predictions and in vivo NMR Experimental Findings

S Mangia, F Giove, I Tkáč… - Journal of Cerebral …, 2009 - journals.sagepub.com
Unraveling the energy metabolism and the hemodynamic outcomes of excitatory and
inhibitory neuronal activity is critical not only for our basic understanding of overall brain …

Specificity of stimulus-evoked fMRI responses in the mouse: the influence of systemic physiological changes associated with innocuous stimulation under four different …

A Schroeter, F Schlegel, A Seuwen, J Grandjean… - Neuroimage, 2014 - Elsevier
Functional magnetic resonance (fMRI) in mice has become an attractive tool for mechanistic
studies, for characterizing models of human disease, and for evaluation of novel therapies …

Dynamics of changes in blood flow, volume, and oxygenation: implications for dynamic functional magnetic resonance imaging calibration

I Kida, DL Rothman, F Hyder - Journal of Cerebral Blood …, 2007 - journals.sagepub.com
Changes in cerebral blood flow (CBF), volume (CBV), and oxygenation (blood-oxygenation
level dependent (BOLD)) during functional activation are important for calculating changes …

Prospects for quantitative fMRI: investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans

VEM Griffeth, JE Perthen, RB Buxton - Neuroimage, 2011 - Elsevier
Functional magnetic resonance imaging (fMRI) provides an indirect reflection of neural
activity change in the working brain through detection of blood oxygenation level dependent …

Brain or vein oxygenation or flow? On signal physiology in functional MRI of human brain activation

J Frahm, KD Merboldt, W Hänicke… - NMR in …, 1994 - Wiley Online Library
Stimulus‐related signal changes in functional MRI of human brain activation not only reflect
associated adjustments of cerebral blood flow and oxygen consumption, but strongly …

Periods of rest in fMRI contain individual spontaneous events which are related to slowly fluctuating spontaneous activity

N Petridou, CC Gaudes, IL Dryden… - Human brain …, 2013 - Wiley Online Library
Abstract fMRI studies of brain activity at rest study slow (< 0.1 Hz) intrinsic fluctuations in the
blood‐oxygenation‐level‐dependent (BOLD) signal that are observed in a temporal scale of …

[HTML][HTML] Magnetic resonance spectroscopy of the brain: a review of physical principles and technical methods

MH Buonocore, RJ Maddock - Reviews in the Neurosciences, 2015 - degruyter.com
Magnetic resonance spectroscopy (MRS) provides unique information about the
neurobiological substrates of brain function in health and disease. However, many of the …

Oxidative Glucose Metabolism in Rat Brain during Single Forepaw Stimulation: A Spatially Localized 1H[13C] Nuclear Magnetic Resonance Study

F Hyder, DL Rothman, GF Mason… - Journal of Cerebral …, 1997 - journals.sagepub.com
In the α-chloralose-anesthetized rat during single forepaw stimulation, a spatially localized
1H [13C] nuclear magnetic resonance spectroscopic method was used to measure the rate …

Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex

JK Huttunen, O Gröhn, M Penttonen - Neuroimage, 2008 - Elsevier
Understanding the link between the hemodynamic response and the underlying neuronal
activity is important for interpreting functional magnetic resonance (fMRI) signals in human …

The hemodynamic response to somatosensory stimulation in mice depends on the anesthetic used: Implications on analysis of mouse fMRI data

F Schlegel, A Schroeter, M Rudin - Neuroimage, 2015 - Elsevier
In recent years, the number of functional MRI (fMRI) studies in mice has been rapidly
increasing. Technological improvements provide the sensitivity required to match the high …