The physics of functional magnetic resonance imaging (fMRI)

RB Buxton - Reports on Progress in Physics, 2013 - iopscience.iop.org
Functional magnetic resonance imaging (fMRI) is a methodology for detecting dynamic
patterns of activity in the working human brain. Although the initial discoveries that led to …

Characterization of the hemodynamic response function across the majority of human cerebral cortex

AJ Taylor, JH Kim, D Ress - NeuroImage, 2018 - Elsevier
Abstract A brief (< 4 s) period of neural activation evokes a stereotypical sequence of
vascular and metabolic events to create the hemodynamic response function (HRF) …

Synchronized delta oscillations correlate with the resting-state functional MRI signal

H Lu, Y Zuo, H Gu, JA Waltz, W Zhan… - Proceedings of the …, 2007 - National Acad Sciences
Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal
have recently been applied to investigate large-scale neuronal networks of the brain in the …

Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy

F Hyder, RK Fulbright, RG Shulman… - Journal of Cerebral …, 2013 - journals.sagepub.com
Rodent 13C magnetic resonance spectroscopy studies show that glutamatergic signaling
requires high oxidative energy in the awake resting state and allowed calibration of …

Quantitative measurement of cerebral physiology using respiratory-calibrated MRI

DP Bulte, M Kelly, M Germuska, J Xie, MA Chappell… - Neuroimage, 2012 - Elsevier
Functional magnetic resonance imaging typically measures signal increases arising from
changes in the transverse relaxation rate over small regions of the brain and associates …

Baseline brain energy supports the state of consciousness

RG Shulman, F Hyder… - Proceedings of the …, 2009 - National Acad Sciences
An individual, human or animal, is defined to be in a conscious state empirically by the
behavioral ability to respond meaningfully to stimuli, whereas the loss of consciousness is …

A model of the coupling between brain electrical activity, metabolism, and hemodynamics: application to the interpretation of functional neuroimaging

A Aubert, R Costalat - Neuroimage, 2002 - Elsevier
In order to improve the interpretation of functional neuroimaging data, we implemented a
mathematical model of the coupling between membrane ionic currents, energy metabolism …

On the nature of the BOLD fMRI contrast mechanism

NK Logothetis, J Pfeuffer - Magnetic resonance imaging, 2004 - Elsevier
Since its development about 15 years ago, functional magnetic resonance imaging (fMRI)
has become the leading research tool for mapping brain activity. The technique works by …

Functional MRI of calcium‐dependent synaptic activity: cross correlation with CBF and BOLD measurements

TQ Duong, AC Silva, SP Lee… - Magnetic Resonance in …, 2000 - Wiley Online Library
Spatial specificities of the calcium‐dependent synaptic activity, hemodynamic‐based blood
oxygenation level‐dependent (BOLD) and cerebral blood flow (CBF) fMRI were …

Quantitative fMRI and oxidative neuroenergetics

F Hyder, DL Rothman - Neuroimage, 2012 - Elsevier
The discovery of functional magnetic resonance imaging (fMRI) has greatly impacted
neuroscience. The blood oxygenation level-dependent (BOLD) signal, using …