Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi K, Okonofua F, Parnas J,
Schulz LO, Bertranpetit J, Bonne-Tamir B, Lu RB, Kidd JR, Kidd KK (2002) A global …

Alcohol consumption is a complex trait determined by both genetic and environmental
factors, and is correlated with the risk of alcohol use disorders. Although a small number of …

Osier et al.(2002) report that haplotyping of the alcohol dehydrogenase (ADH) gene cluster
at 4q21-23 showed unusually high values for Fst, an estimator of population differentiation …

Alcohol dependence (AD) is an important contributory factor to the global burden of disease.
The etiology of AD involves both environmental and genetic factors, and the disorder has a …

Background: The aim of the present study was to use a candidate gene approach to identify
the genetic risk factors for alcoholism in Mexican Americans residing in the Los Angeles …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

We have previously found that variation in alcohol metabolism in Europeans is linked to the
chromosome 4q region containing the ADH gene family. We have now typed 103 single …

Background: The genes coding for ethanol metabolism enzymes [alcohol dehydrogenase
(ADH) and aldehyde dehydrogenase (ALDH)] have been widely studied for their influence …

Background Habitual alcohol use can be an indicator of alcohol dependence, which is
associated with a wide range of serious health problems. Methods We completed a genome …

Natural selection is a significant force that shapes the architecture of the human genome
and introduces diversity across global populations. The question of whether advantageous …