Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases
BACKGROUND: The alcohol dehydrogenase 1B gene (ADH1B) is hypothesized to affect
predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene …
predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
RK Walters, R Polimanti, EC Johnson… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …
polygenic architecture or its genetic relationship with other disorders. To discover loci …
[HTML][HTML] ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review
Variants of three genes encoding alcohol-metabolizing enzymes, the aldehyde
dehydrogenase gene ALDH2 and the alcohol dehydrogenase genes ADH1B and ADH1C …
dehydrogenase gene ALDH2 and the alcohol dehydrogenase genes ADH1B and ADH1C …
Genome‐wide association studies of alcohol dependence, DSM‐IV criterion count and individual criteria
Genome‐wide association studies (GWAS) of alcohol dependence (AD) have reliably
identified variation within alcohol metabolizing genes (eg, ADH1B) but have inconsistently …
identified variation within alcohol metabolizing genes (eg, ADH1B) but have inconsistently …
Candidate gene studies of ADHD: a meta-analytic review
IR Gizer, C Ficks, ID Waldman - Human genetics, 2009 - Springer
Quantitative genetic studies (ie, twin and adoption studies) suggest that genetic influences
contribute substantially to the development of attention deficit hyperactivity disorder (ADHD) …
contribute substantially to the development of attention deficit hyperactivity disorder (ADHD) …
Detecting genomic signatures of natural selection with principal component analysis: application to the 1000 genomes data
N Duforet-Frebourg, K Luu, G Laval… - Molecular biology …, 2016 - academic.oup.com
To characterize natural selection, various analytical methods for detecting candidate
genomic regions have been developed. We propose to perform genome-wide scans of …
genomic regions have been developed. We propose to perform genome-wide scans of …
[HTML][HTML] Biology, genetics, and environment: underlying factors influencing alcohol metabolism
Gene variants encoding several of the alcohol-metabolizing enzymes, alcohol
dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), are among the largest …
dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), are among the largest …
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis
HJ Edenberg, X Xuei, HJ Chen, H Tian… - Human molecular …, 2006 - academic.oup.com
Linkage evidence indicated that gene (s) located on chromosome 4q, in the region of the
alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single …
alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single …
Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.
This reprinted article originally appeared in Psychological Bulletin, 2006, Vol 132 (4), 607-
621.(The following abstract of the original article appeared in record 2006-08436-008.) Meta …
621.(The following abstract of the original article appeared in record 2006-08436-008.) Meta …