Genome-wide association studies (GWAS) have underrepresented individuals from non-
European populations, impeding progress in characterizing the genetic architecture and …

In this issue of GENETICS, a new method for detecting natural selection on polygenic traits
is developed and applied to several human examples (Racimo et al. 2018). By definition …

Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …

Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral …

Identifying regions of the human genome that have been targets of positive selection will
provide important insights into recent human evolutionary history and may facilitate the …

It is important to study the genetics of complex traits in diverse populations. Here, we
introduce covariate-adjusted linkage disequilibrium (LD) score regression (cov-LDSC), a …

There has recently been considerable interest in detecting natural selection in the human
genome. Selection will usually tend to increase identity-by-descent (IBD) among individuals …

We present a full-likelihood method to infer polygenic adaptation from DNA sequence
variation and GWAS summary statistics to quantify recent transient directional selection …

Population genetics is transitioning into a data-driven discipline thanks to the availability of
large-scale genomic data and the need to study increasingly complex evolutionary …

The allele frequency spectrum of polymorphisms in DNA sequences can be used to test for
signatures of natural selection that depart from the expected frequency spectrum under the …