Molecular Insight into the Structure, Function, and Regulation of Bile Acid Transport

LC Czuba - 2017 - search.proquest.com
Abstract The human Apical Sodium-dependent Bile Acid Transporter (SLC10A2), also
known as hASBT, plays an integral role in the enterohepatic circulation of bile acid and …

Understanding structure-function relationships and protein stability of the human apical sodium-dependent bile acid transporter (ASBT, SLC10A2)

TC da Silva - 2011 - search.proquest.com
The apical sodium-dependent bile acid transporter (ASBT, SLC10A2) is renowned as the
major bile acid transporter in the intestine. It utilizes cellular sodium gradient to actively …

UNDERSTANDING STRUCTURE-FUNCTION RELATIONSHIPS AND PROTEIN STABILITY OF THE HUMAN APICAL SODIUM-DEPENDENT BILE ACID …

T Claro da Silva - 2011 - archive.hshsl.umaryland.edu
The apical sodium-dependent bile acid transporter (ASBT, SLC10A2) is renowned as the
major bile acid transporter in the intestine. It utilizes cellular sodium gradient to actively …

Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation

H Sabit, SS Mallajosyula, AD MacKerell… - Journal of Biological …, 2013 - ASBMB
Human apical sodium-dependent bile acid transporter (hASBT, SLC10A2) is responsible for
intestinal reabsorption of bile acids and plays a key role in cholesterol homeostasis. We …

Structural Basis of Bile Acid Transport

M Zhou - The FASEB Journal, 2015 - Wiley Online Library
Bile acids are synthesized from cholesterol in hepatocytes and secreted through the biliary
tract into the small intestine, where they aid in absorption of lipids and fat‐soluble vitamins …

Transmembrane domain VII of the human apical sodium-dependent bile acid transporter ASBT (SLC10A2) lines the substrate translocation pathway

N Hussainzada, A Banerjee, PW Swaan - Molecular pharmacology, 2006 - ASPET
Recent evidence implicating transmembrane (TM) segment 7 of the apical sodium-
dependent bile acid transporter (ASBT) in substrate interaction warranted examination of its …

[HTML][HTML] Human bile acid transporter ASBT (SLC10A2) forms functional non-covalent homodimers and higher order oligomers

PP Chothe, LC Czuba, RH Moore… - Biochimica et Biophysica …, 2018 - Elsevier
The human apical sodium-dependent bile acid transporter, hASBT/SLC10A2, plays a central
role in cholesterol homeostasis via the efficient reabsorption of bile acids from the distal …

Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2

TC da Silva, N Hussainzada, CM Khantwal… - Journal of Biological …, 2011 - ASBMB
The human apical sodium-dependent bile acid transporter (hASBT, SLC10A2) plays a
critical role in the enterohepatic circulation of bile acids, as well as in cholesterol …

[图书][B] Membrane topology and structure-function relationship of the Apical Sodium-dependent Bile Acid Transporter, ASBT

Y Zhang - 2001 - search.proquest.com
The apical sodium-dependent bile acid transporter (ASBT) is a member of the solute carrier
transporter superfamily and an essential component of enterohepatic circulation. ASBT has …

[图书][B] Inhibition and substrate requirements of human apical sodium-dependent bile acid transporter (ASBT) and its potential as a prodrug target

X Zheng - 2010 - search.proquest.com
The human apical sodium-dependent bile acid transporter (ASBT; SLC10A2) is an important
mechanism for intestinal bile acid reabsorption and plays a critical role in bile acid and …