[HTML][HTML] Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within …
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social
behavior and cognition and what is the optimal dose for OT response. To better understand …
behavior and cognition and what is the optimal dose for OT response. To better understand …
Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men
Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala
responses to fear-related stimuli in men, while exerting inverse effects in women. However …
responses to fear-related stimuli in men, while exerting inverse effects in women. However …
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …
A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …
In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …
Oxytocin and brain activity in humans: a systematic review and coordinate-based meta-analysis of functional MRI studies
SA Grace, SL Rossell, M Heinrichs… - …, 2018 - Elsevier
Oxytocin (OXT) is a neuropeptide which has a critical role in human social behaviour and
cognition. Research investigating the role of OXT on functional brain changes in humans …
cognition. Research investigating the role of OXT on functional brain changes in humans …
[HTML][HTML] The effect of intranasal oxytocin on neural response to facial emotions in healthy adults as measured by functional MRI: a systematic review
Abnormalities in responses to human facial emotions are associated with a range of
psychiatric disorders. Addressing these abnormalities may therefore have significant clinical …
psychiatric disorders. Addressing these abnormalities may therefore have significant clinical …
Distinct BOLD activation profiles following central and peripheral oxytocin administration in awake rats
A growing body of literature has suggested that intranasal oxytocin (OT) or other systemic
routes of administration can alter prosocial behavior, presumably by directly activating OT …
routes of administration can alter prosocial behavior, presumably by directly activating OT …
Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat
emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of …
emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of …
[HTML][HTML] “Less is more”: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain
D Martins, K Brodmann, M Veronese… - Progress in …, 2022 - Elsevier
Intranasal oxytocin is attracting attention as a potential treatment for several brain disorders
due to promising preclinical results. However, translating findings to humans has been …
due to promising preclinical results. However, translating findings to humans has been …
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