[HTML][HTML] Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within …

DS Quintana, LT Westlye, D Alnæs, ØG Rustan… - …, 2016 - Elsevier
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social
behavior and cognition and what is the optimal dose for OT response. To better understand …

Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men

J Lieberz, D Scheele, FB Spengler… - …, 2020 - nature.com
Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala
responses to fear-related stimuli in men, while exerting inverse effects in women. However …

Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity

FB Spengler, J Schultz, D Scheele, M Essel, W Maier… - Biological …, 2017 - Elsevier
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …

A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …

In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

J Kou, C Lan, Y Zhang, Q Wang, F Zhou, Z Zhao… - Translational …, 2021 - nature.com
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …

Oxytocin and brain activity in humans: a systematic review and coordinate-based meta-analysis of functional MRI studies

SA Grace, SL Rossell, M Heinrichs… - …, 2018 - Elsevier
Oxytocin (OXT) is a neuropeptide which has a critical role in human social behaviour and
cognition. Research investigating the role of OXT on functional brain changes in humans …

[HTML][HTML] The effect of intranasal oxytocin on neural response to facial emotions in healthy adults as measured by functional MRI: a systematic review

J Tully, AS Gabay, D Brown, DGM Murphy… - Psychiatry Research …, 2018 - Elsevier
Abnormalities in responses to human facial emotions are associated with a range of
psychiatric disorders. Addressing these abnormalities may therefore have significant clinical …

Distinct BOLD activation profiles following central and peripheral oxytocin administration in awake rats

CF Ferris, JR Yee, WM Kenkel, KM Dumais… - Frontiers in behavioral …, 2015 - frontiersin.org
A growing body of literature has suggested that intranasal oxytocin (OT) or other systemic
routes of administration can alter prosocial behavior, presumably by directly activating OT …

Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies

D Wang, X Yan, M Li, Y Ma - Social Cognitive and Affective …, 2017 - academic.oup.com
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat
emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of …

[HTML][HTML] “Less is more”: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain

D Martins, K Brodmann, M Veronese… - Progress in …, 2022 - Elsevier
Intranasal oxytocin is attracting attention as a potential treatment for several brain disorders
due to promising preclinical results. However, translating findings to humans has been …