TRAF6 signaling pathway in T cells regulates anti-tumor immunity through the activation of tumor specific Th9 cells and CTLs
A Dewayani, N Kamiyama, N Sachi, S Ozaka… - Biochemical and …, 2022 - Elsevier
CD8+ cytotoxic T lymphocytes (CTLs) and CD4+ helper T (Th) cells play a critical role in
protective immune responses to tumor cells. Particularly, Th9 cells exert anti-tumor activity …
protective immune responses to tumor cells. Particularly, Th9 cells exert anti-tumor activity …
Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice
AI Lalani, CR Moore, C Luo, BZ Kreider… - The Journal of …, 2015 - journals.aai.org
Myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells, are
crucial players in innate immunity and inflammation. These cells constitutively or inducibly …
crucial players in innate immunity and inflammation. These cells constitutively or inducibly …
TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells
TNF receptor associated factor 6 (TRAF6) plays a critical role in the regulation of innate
immune responses and adaptive immune responses. Though recent studies indicate that …
immune responses and adaptive immune responses. Though recent studies indicate that …
Mechanism by which TRAF6 participates in the immune regulation of autoimmune diseases and cancer
J Wang, X Wu, M Jiang, G Tai - BioMed research international, 2020 - Wiley Online Library
Tumor necrosis factor (TNF) receptor‐associated factor 6 (TRAF6), an E3 ubiquitin ligase, is
a signal transduction molecule shared by the interleukin‐1 receptor (IL‐1R)/Toll‐like …
a signal transduction molecule shared by the interleukin‐1 receptor (IL‐1R)/Toll‐like …
Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer
Tumor necrosis factor (TNF) receptor–associated factor 3 (TRAF3) regulates both innate and
adaptive immunity by modulating signaling by Toll-like receptors (TLR) and TNF receptors …
adaptive immunity by modulating signaling by Toll-like receptors (TLR) and TNF receptors …
Roles of TRAF3 in T cells: many surprises
Z Yi, AM Wallis, GA Bishop - Cell Cycle, 2015 - Taylor & Francis
Tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) is broadly involved in
different receptor-mediated signaling pathways. Considerable progress was made recently …
different receptor-mediated signaling pathways. Considerable progress was made recently …
TRAF2 regulates peripheral CD8+ T‐cell and NKT‐cell homeostasis by modulating sensitivity to IL‐15
JE Villanueva, EK Malle, S Gardam… - European Journal of …, 2015 - Wiley Online Library
In this study, a critical and novel role for TNF receptor (TNFR) associated factor 2 (TRAF2) is
elucidated for peripheral CD8+ T‐cell and NKT‐cell homeostasis. Mice deficient in TRAF2 …
elucidated for peripheral CD8+ T‐cell and NKT‐cell homeostasis. Mice deficient in TRAF2 …
Traf6 inhibitor boosts antitumor immunity by impeding regulatory T cell migration in Hepa1-6 tumor model
X Wu, R Xue, H Peng, X Gan, X Lu, W Yan… - International …, 2019 - Elsevier
Tumors escape immune attacks via various mechanisms, among which activation of
regulatory pathways in effector immune cells and recruitment of immunosuppressive cells …
regulatory pathways in effector immune cells and recruitment of immunosuppressive cells …
TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity
Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory
responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by …
responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by …
Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many
physiological processes. Here we studied the phenotype of TRAF6 [L74H] knock-in mice …
physiological processes. Here we studied the phenotype of TRAF6 [L74H] knock-in mice …