CD8+ cytotoxic T lymphocytes (CTLs) and CD4+ helper T (Th) cells play a critical role in
protective immune responses to tumor cells. Particularly, Th9 cells exert anti-tumor activity …

Myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells, are
crucial players in innate immunity and inflammation. These cells constitutively or inducibly …

TNF receptor associated factor 6 (TRAF6) plays a critical role in the regulation of innate
immune responses and adaptive immune responses. Though recent studies indicate that …

Tumor necrosis factor (TNF) receptor‐associated factor 6 (TRAF6), an E3 ubiquitin ligase, is
a signal transduction molecule shared by the interleukin‐1 receptor (IL‐1R)/Toll‐like …

Tumor necrosis factor (TNF) receptor–associated factor 3 (TRAF3) regulates both innate and
adaptive immunity by modulating signaling by Toll-like receptors (TLR) and TNF receptors …

Tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) is broadly involved in
different receptor-mediated signaling pathways. Considerable progress was made recently …

In this study, a critical and novel role for TNF receptor (TNFR) associated factor 2 (TRAF2) is
elucidated for peripheral CD8+ T‐cell and NKT‐cell homeostasis. Mice deficient in TRAF2 …

Tumors escape immune attacks via various mechanisms, among which activation of
regulatory pathways in effector immune cells and recruitment of immunosuppressive cells …

Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory
responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by …

The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many
physiological processes. Here we studied the phenotype of TRAF6 [L74H] knock-in mice …