Cytokines are key instigators and regulators of immune responses and therefore hold great
potential as targets for new therapeutic strategies. However, the selection of which cytokines …

Proinflammatory cytokines are potent mediators of numerous biological processes and are
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Acute inflammation normally resolves by mechanisms that have remained somewhat
elusive. Emerging evidence now suggests that an active, coordinated program of resolution …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Commentary Page 1 Immunity Commentary Cytokines as Therapeutic Targets: Advances and
Limitations Clemens Scheinecker,1 Kurt Redlich,1 and Josef S. Smolen1,* 1Division of …

Immune-mediated inflammatory diseases are common and clinically diverse. Although they
are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory …

An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

This series of reviews addresses mechanisms whereby inflammation can be reduced,
turned off or perhaps prevented, both in the context of natural dampening processes as well …

Inflammatory diseases are a major burden on humanity, despite recent successes with
biopharmaceuticals. Lack of responsiveness and resistance to these drugs, delivery …