A necroptosis related prognostic model of pancreatic cancer based on single cell sequencing analysis and transcriptome analysis

L Chen, X Zhang, Q Zhang, T Zhang, J Xie… - Frontiers in …, 2022 - frontiersin.org
Background As a tumor type with high mortality and poor therapeutic effect, the
pathogenesis of pancreatic cancer is still unclear. It is necessary to explore the significance …

[HTML][HTML] Pyroptosis-related lncRNA pairs to estimate the molecular features and prognostic outcomes of pancreatic ductal adenocarcinoma

SY Lu, J Hua, J Liu, MY Wei, C Liang, QC Meng… - Translational …, 2022 - Elsevier
Pyroptosis is a form of programmed cell death associated with inflammatory alterations.
However, the intrinsic mechanisms and underlying correlation of pyroptosis-related lncRNAs …

Identification of a ubiquitination-related gene risk model for predicting survival in patients with pancreatic cancer

H Zuo, L Chen, N Li, Q Song - Frontiers in Genetics, 2020 - frontiersin.org
Pancreatic cancer is known as “the king of cancer,” and ubiquitination/deubiquitination-
related genes are key contributors to its development. Our study aimed to identify …

Identification of fibroblast-related genes based on single-cell and machine learning to predict the prognosis and endocrine metabolism of pancreatic cancer

Y Xu, X Chen, N Liu, Z Chu, Q Wang - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Single-cell sequencing technology has become an indispensable tool in tumor
mechanism and heterogeneity studies. Pancreatic adenocarcinoma (PAAD) lacks early …

[HTML][HTML] RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4

MK Kirby, RC Ramaker, J Gertz, NS Davis… - Molecular …, 2016 - Elsevier
Background Pancreatic adenocarcinoma patients have low survival rates due to late-stage
diagnosis and high rates of cancer recurrence even after surgical resection. It is important to …

A comprehensive analysis of pyroptosis-related lncRNAs signature associated with prognosis and tumor immune microenvironment of pancreatic adenocarcinoma

K Zhao, X Li, Y Shi, Y Lu, P Qiu, Z Deng, W Yao… - Frontiers in …, 2022 - frontiersin.org
Background: Globally, pancreatic adenocarcinoma (PAAD) is a common and highly
devastating gastrointestinal malignancy that seriously threatens human health. Pyroptosis …

Bioinformatics analysis of a prognostic miRNA signature and potential key genes in pancreatic cancer

S Chen, C Gao, T Yu, Y Qu, GG Xiao, Z Huang - Frontiers in oncology, 2021 - frontiersin.org
Background In this study, miRNAs and their critical target genes related to the prognosis of
pancreatic cancer were screened based on bioinformatics analysis to provide targets for the …

Single-cell sequencing and establishment of an 8-gene prognostic model for pancreatic cancer patients

X Yu, Q Zhang, S Zhang, Y He, W Guo - Frontiers in Oncology, 2022 - frontiersin.org
Background Single-cell sequencing (SCS) technologies enable analysis of gene structure
and expression data at single-cell resolution. However, SCS analysis in pancreatic cancer …

[HTML][HTML] The lncRNAs MIR600HG and TSPOAP1-AS1 may potentially act as biomarkers for predicting pancreatic cancer

J Tian, Y Wang - Translational Cancer Research, 2020 - ncbi.nlm.nih.gov
Background The purpose of this study was to assess long non-coding RNAs (lncRNAs) as
biomarkers of pancreatic cancer (PC). Methods The Cancer Genome Atlas (TCGA) database …

Construction and comprehensive analysis of a novel prognostic signature associated with pyroptosis molecular subtypes in patients with pancreatic adenocarcinoma

Q Huang, X Peng, Q Li, J Zhu, J Xue… - Frontiers in …, 2023 - frontiersin.org
Background Treatment of cancer with pyroptosis is an emerging strategy. Molecular
subtypes based on pyroptosis-related genes (PRGs) seem to be considered more …