S-glutathionylation enhances human cystathionine β-synthase activity under oxidative stress conditions

WN Niu, PK Yadav, J Adamec… - Antioxidants & redox …, 2015 - liebertpub.com
Aims: Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-
step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three …

Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond

W Niu, J Wang, J Qian, M Wang, P Wu, F Chen… - Journal of Biological …, 2018 - ASBMB
Cystathionine β-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that
converts homocysteine to cysteine. It is also one of the three major enzymes involved in the …

H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine

M Petrosino, K Zuhra, J Kopec, A Hutchin… - Cellular and Molecular …, 2022 - Springer
Cystathionine beta-synthase (CBS) is a pivotal enzyme of the transsulfuration pathway
responsible for diverting homocysteine to the biosynthesis of cysteine and production of …

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

K Zuhra, F Augsburger, T Majtan, C Szabo - Biomolecules, 2020 - mdpi.com
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Biogenesis of hydrogen sulfide and thioethers by cystathionine beta-synthase

T Majtan, J Krijt, J Sokolová, M Křížková… - Antioxidants & redox …, 2018 - liebertpub.com
Aims: The transsulfuration pathway enzymes cystathionine beta-synthase (CBS) and
cystathionine gamma-lyase are thought to be the major source of hydrogen sulfide (H2S). In …

The role of cystathionine β-synthase in homocysteine metabolism

KH Jhee, WD Kruger - Antioxidants & redox signaling, 2005 - liebertpub.com
Cystathionine β-synthase (CBS) is the first enzyme in the transsulfuration pathway,
catalyzing the conversion of serine and homocysteine to cystathionine and water. The …

S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity

A Prudova, Z Bauman, A Braun… - Proceedings of the …, 2006 - National Acad Sciences
The transsulfuration pathway converts homocysteine to cysteine and represents the
metabolic link between antioxidant and methylation metabolism. The first and committing …

Ischemia/reperfusion reduces transcription factor Sp1-mediated cystathionine β-synthase expression in the kidney

N Wu, YL Siow, O Karmin - Journal of Biological Chemistry, 2010 - ASBMB
Cystathionine β-synthase (CBS) is a key enzyme that catalyzes the rate-limiting step for
homocysteine (Hcy) metabolism via the trans-sulfuration pathway and is also responsible for …

Dioxygen reactivity and heme redox potential of truncated human cystathionine β-synthase

S Carballal, P Madzelan, CF Zinola, M Graña… - Biochemistry, 2008 - ACS Publications
Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to
cystathionine, which represents the committing step in the transsulfuration pathway. CBS is …

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine

J Ereño-Orbea, T Majtan, I Oyenarte… - Proceedings of the …, 2014 - National Acad Sciences
Cystathionine β-synthase (CBS) is a heme-dependent and pyridoxal-5′-phosphate–
dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of …