α-Synuclein is a key molecule in understanding the pathogenesis of neurodegenerative α-
synucleinopathies such as Parkinson's disease. Despite extensive research, however, its …

α-Synuclein is an abundant presynaptic protein that binds to phospholipids and synaptic
vesicles. Physiologically, α-synuclein functions as a SNARE-protein chaperone that …

In recent years, two developments have imparted a new direction to research on the
aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense …

Misfolding and aggregation of alpha‐synuclein (α‐synuclein) with concomitant cytotoxicity is
a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy …

Aggregation of α-synuclein contributes to the formation of Lewy bodies and neurites, the
pathologic hallmarks of Parkinson disease (PD) and α-synucleinopathies. Although a …

Alpha-synuclein is a 140 amino acid neuronal protein that has been associated with several
neurodegenerative diseases. A point mutation in the gene coding for the α-synuclein protein …

Abstract α-Synuclein, the major component of Lewy bodies (LBs) and Lewy neurites (LNs),
is expressed in presynapses under physiologically normal conditions and is involved in …

Alzheimer's disease (AD) and Lewy body disease (LBD) are the most common causes of
dementia in the elderly population. Previous studies have shown that cognitive alterations in …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar
aggregates of α-synuclein in characteristic inclusions known as 'Lewy bodies'. As mutations …

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …