Abnormal accumulation of α‐synuclein (α‐syn) has been linked to several neurological
disorders, including Parkinson's disease (PD). However, the underlying mechanism by …

Parkinson's disease (PD) is a chronic progressive neurodegenerative disease, which is
characterized by severe loss of dopaminergic neurons and formation of Lewy bodies, which …

Cytoplasmic deposition of α-synuclein aggregates is a common pathological feature of many
neurodegenerative diseases. Strong evidence for the causative role of α-synuclein in these …

In Parkinson's disease, intracellular α-synuclein inclusions form in neurons. We suggest that
prion-like behavior of α-synuclein is a key component in Parkinson's disease pathogenesis …

Parkinson's disease (PD) is one of the synucleinopathies spectrum of disorders typified by
the presence of intraneuronal protein inclusions. It is primarily composed of misfolded and …

Abstract α-Synuclein deposited in Lewy bodies, a pathological hallmark of Parkinson's
disease (PD), is highly phosphorylated at serine 129 (Ser129). In contrast, there is very little …

Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

ABSTRACT α‐Synuclein, the major constituent of Lewy bodies (LBs), is normally expressed
in presynapses and is involved in synaptic function. Abnormal intracellular aggregation of α …

Selective loss of neurons, abnormal protein deposition and neuroinflammation are the
common pathological features of neurodegenerative diseases, and these features are …

Abstract α-Synuclein is the major component of filamentous inclusions that constitute the
defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular …