The maintenance of the proteome is essential to preserve cell functionality and the ability to
respond and adapt to the changing environment. This is regulated by the proteostasis …

Degradation and Accumulation of Oxidized Proteins in Ageâ•’Related Diseases Page 1 17
DEGRADATION AND ACCUMULATION OF OXIDIZED PROTEINS IN AGE-RELATED …

Recent statistics indicate that the human population is ageing rapidly. Healthy, but also
diseased, elderly people are increasing. This trend is particularly evident in Western …

Aging is a multifactorial process characterized by a gradual loss of physiological functions,
which leads to increased vulnerability of the organism to age-related diseases and, finally, to …

This review covers the application of mass spectrometric techniques to aging research.
Modern proteomic strategies will be discussed as well as the targeted analysis of specific …

Analogous to the term genomics, proteomics is defined as the analysis of the entire protein
complement expressed by a genome. However, proteomics is more diverse than genomics …

Publisher Summary Alzheimer's disease (AD) is a progressive, age-related
neurodegenerative disorder associated with cognitive decline and aging. A number of …

Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as
the decline of functional capacity and stress resistance, is different in every individual. There …

Despite extensive studies, the molecular basis of physiological aging is still poorly
understood. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) as well as …

Progressive loss of proteostasis is a hallmark of aging that is marked by declines in various
components of proteostasis machinery, including: autophagy, ubiquitin‐mediated …