Curcumin and neurodegenerative diseases: a perspective

AS Darvesh, RT Carroll, A Bishayee… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Curcumin, a dietary polyphenol found in the curry spice turmeric, possesses
potent antioxidant and anti-inflammatory properties and an ability to modulate multiple …

Curcumin as a potential treatment for Alzheimer's disease: a study of the effects of curcumin on hippocampal expression of glial fibrillary acidic protein

Y Wang, H Yin, L Wang, A Shuboy, J Lou… - The American journal …, 2013 - World Scientific
Curcumin, an agent traditionally utilized for its preventative action against tumorigenesis,
oxidation, inflammation, apoptosis and hyperlipemia, has also been used in the treatment of …

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

D Yanagisawa, NF Ibrahim, H Taguchi, S Morikawa… - Neurobiology of …, 2015 - Elsevier
Recent evidence supports the amyloid cascade hypothesis that a pathological change of
amyloid β (Aβ) in the brain is an initiating event in Alzheimer's disease (AD). Accordingly …

Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo

F Yang, GP Lim, AN Begum, OJ Ubeda… - Journal of Biological …, 2005 - ASBMB
Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and
inflammation, and risk is reduced with increased antioxidant and anti-inflammatory …

Post-ischemic brain neurodegeneration in the form of Alzheimer's disease proteinopathy: Possible therapeutic role of curcumin

R Pluta, W Furmaga-Jabłońska, S Januszewski… - Nutrients, 2022 - mdpi.com
For thousands of years, mankind has been using plant extracts or plants themselves as
medicinal herbs. Currently, there is a great deal of public interest in naturally occurring …

Curcumin as prospective anti-aging natural compound: focus on brain

T Benameur, R Soleti, MA Panaro, ME La Torre… - Molecules, 2021 - mdpi.com
The nutrients and their potential benefits are a new field of study in modern medicine for
their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from …

New promising therapeutic avenues of curcumin in brain diseases

T Benameur, G Giacomucci, MA Panaro, M Ruggiero… - Molecules, 2021 - mdpi.com
Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used
as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also …

Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

M Garcia‐Alloza, LA Borrelli, A Rozkalne… - Journal of …, 2007 - Wiley Online Library
Alzheimer's disease (AD) is characterized by senile plaques and neurodegeneration
although the neurotoxic mechanisms have not been completely elucidated. It is clear that …

Curcumin decreases amyloid-β peptide levels by attenuating the maturation of amyloid-β precursor protein

C Zhang, A Browne, D Child, RE Tanzi - Journal of Biological Chemistry, 2010 - ASBMB
Alzheimer disease (AD) is a devastating neurodegenerative disease with no cure. The
pathogenesis of AD is believed to be driven primarily by amyloid-β (Aβ), the principal …

Curcumin and its derivatives as theranostic agents in Alzheimer's disease: The implication of nanotechnology

U Shabbir, M Rubab, A Tyagi, DH Oh - International Journal of Molecular …, 2020 - mdpi.com
Curcumin is a polyphenolic natural compound with diverse and attractive biological
properties, which may prevent or ameliorate pathological processes underlying age-related …