Curcumin's nanomedicine formulations for therapeutic application in neurological diseases

B Salehi, D Calina, AO Docea, N Koirala… - Journal of Clinical …, 2020 - mdpi.com
The brain is the body's control center, so when a disease affects it, the outcomes are
devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases …

PPARγ agonist curcumin reduces the amyloid-β-stimulated inflammatory responses in primary astrocytes

HM Wang, YX Zhao, S Zhang, GD Liu… - Journal of …, 2010 - content.iospress.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder.
Accumulating data indicate that astrocytes play an important role in the neuroinflammation …

Curcumin attenuates amyloid-β aggregate toxicity and modulates amyloid-β aggregation pathway

A Thapa, SD Jett, EY Chi - ACS chemical neuroscience, 2016 - ACS Publications
The abnormal misfolding and aggregation of amyloid-β (Aβ) peptides into β-sheet enriched
insoluble deposits initiates a cascade of events leading to pathological processes and …

Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies

MR Sarker, SF Franks - Geroscience, 2018 - Springer
Processes such as aberrant redox signaling and chronic low-grade systemic inflammation
have been reported to modulate age-associated pathologies such as cognitive impairment …

Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3β signaling pathway

JB Hoppe, K Coradini, RL Frozza, CM Oliveira… - Neurobiology of learning …, 2013 - Elsevier
Abstract Alzheimer's disease (AD), a neurodegenerative disorder exhibiting progressive loss
of memory and cognitive functions, is characterized by the presence of neuritic plaques …

Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease

AN Begum, MR Jones, GP Lim, T Morihara… - … of Pharmacology and …, 2008 - ASPET
Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and
metabolism raise concerns, including whether the more stable metabolite …

Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

B Ray, DK Lahiri - Current opinion in pharmacology, 2009 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. Deposition of
amyloid β plaque and associated neuroinflammation are the major hallmarks of AD …

Curcumin and neurodegenerative diseases

A Monroy, GJ Lithgow, S Alavez - Biofactors, 2013 - Wiley Online Library
Over the last 10 years curcumin has been reported to be effective against a wide variety of
diseases and is characterized as having anticarcinogenic, hepatoprotective …

Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century

WH Lee, CY Loo, M Bebawy, F Luk… - Current …, 2013 - ingentaconnect.com
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

Reversal of beta-amyloid-induced neurotoxicity in PC12 cells by curcumin, the important role of ROS-mediated signaling and ERK pathway

C Fan, Y Li, X Fu, Q Wu, Y Hou, M Yang, J Sun… - Cellular and molecular …, 2017 - Springer
Progressive accumulation of beta-amyloid (Aβ) will form the senile plaques and cause
oxidative damage and neuronal cell death, which was accepted as the major pathological …